PARP1/2-IN-3 is a potent inhibitor of PARP1 and PARP2, exhibiting IC50 values of 0.2235 nM and <0.001 nM, respectively. This compound effectively inhibits the proliferation of Capan-1 wildtype and AZD2281 or BMN673-resistant cells, with IC50 values ranging from 1.82 to 9.98 nM. Additionally, PARP1/2-IN-3 demonstrates significant antitumor efficacy in murine models, making it a valuable tool for cancer research and therapeutic development targeting PARP pathways.
PARP1/2-IN-3 is a potent inhibitor of PARP1 and PARP2, exhibiting IC50 values of 0.2235 nM and <0.001 nM, respectively. This compound effectively inhibits the proliferation of Capan-1 wildtype and AZD2281 or BMN673-resistant cells, with IC50 values ranging from 1.82 to 9.98 nM. Additionally, PARP1/2-IN-3 demonstrates significant antitumor efficacy in murine models, making it a valuable tool for cancer research and therapeutic development targeting PARP pathways.
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