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- Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851
Biological Activity
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively.
Targets
| AT2 receptor | ||||
| 34 nM |
| In vitro (25°C) | DMSO | 87 mg/mL (171.05 mM) | |
| Water | 87 mg/mL (171.05 mM) | ||
| Ethanol | 87 mg/mL (171.05 mM) | ||
| In vivo | Saline | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.57 mL | 67.87 mL | 135.75 mL |
| 0.5 mM | 2.71 mL | 13.57 mL | 27.15 mL |
| 1 mM | 1.36 mL | 6.79 mL | 13.57 mL |
| 5 mM | 0.27 mL | 1.36 mL | 2.71 mL |
*The above data is based on the productmolecular weight 736.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13201 |
|---|---|
| Actions | Antagonist |
| CAS No. | 136676-91-0 (TFA), 130663-39-7 |
| Formula | C31H32N4O3.2CF3CO2H |
| M. Wt | 736.67 |
| Purity | >98% |
| Synonyms | PD123319, PD-123319 |
| SMILES | CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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