Pemetrexed (Alimta)

Catalog No.: A10707

Pemetrexed (Alimta)

Pemetrexed (Alimta) Chemical Structure

CAS NO. 150399-23-8

Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $70.00

Special Price $63.00

50 mg

Regular Price: $200.00

Special Price $180.00

100 mg

Regular Price: $350.00

Special Price $315.00

200 mg

Regular Price: $600.00

Special Price $540.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.
Targets
TS (Cell-free assay) DHFR (Cell-free assay) GARFT (Cell-free assay)
1.3 nM(Ki)7.2 nM(Ki)65 nM(Ki)
In vitro (25°C) DMSO <1 mg/mL (<1 mM)
Water 94 mg/mL (199.41 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.07 mL 212.13 mL
0.5 mM 4.24 mL 21.21 mL 42.43 mL
1 mM 2.12 mL 10.61 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10707
Actions N/A
M. Wt 471.4
Formula C20H19N5Na2O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 150399-23-8
Synonyms LY-231514, LY231514
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[[email protected]@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

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