PF-06751979

Catalog No.: A20066

BACE1 inhibitor

PF-06751979

PF-06751979 Chemical Structure

CAS NO. 1818339-66-0

PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$550.00
50 mg
$1,800.00
100 mg
$2,500.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF-06751979 is a potent, brain penetrant, β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 7.3 nM in BACE1 binding assay.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.95 mL 109.77 mL 219.54 mL
0.5 mM 4.39 mL 21.95 mL 43.91 mL
1 mM 2.2 mL 10.98 mL 21.95 mL
5 mM 0.44 mL 2.2 mL 4.39 mL

*The above data is based on the productmolecular weight 455.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20066
Actions Inhibitor
CAS No. 1818339-66-0
Formula C18H19F2N5O3S2
M. Wt 455.5
Purity >98%
Synonyms PF 06751979, PF06751979
SMILES FC(F)OC1=CN=C(C(NC2=CSC([[email protected]]34CO[[email protected]@H](C)C[[email protected]@]3([H])CSC(N)=N4)=N2)=O)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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