Pibrozelesin is a derivative of the antibiotic Duocarmycin B2, primarily targeting DNA cleavage. It demonstrates potent antitumor activity, inhibiting the proliferation of H69 cells with an IC50 of 1.9 μM. Upon activation by carboxyl esterase, Pibrozelesin induces DNA strand breaks, making it a valuable tool for cancer research and the study of DNA damage mechanisms.
Pibrozelesin is a derivative of the antibiotic Duocarmycin B2, primarily targeting DNA cleavage. It demonstrates potent antitumor activity, inhibiting the proliferation of H69 cells with an IC50 of 1.9 μM. Upon activation by carboxyl esterase, Pibrozelesin induces DNA strand breaks, making it a valuable tool for cancer research and the study of DNA damage mechanisms.
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