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- Weizhen Chen, .et al. An improved osseointegration of metal implants by pitavastatin loaded multilayer films with osteogenic and angiogenic properties, Biomaterials, 2021, 280:121260 PMID: 34823885
- Karis Tutuska, .et al. Statin as anti-cancer therapy in autochthonous T-lymphomas expressing stabilized gain-of-function mutant p53 proteins, Cell Death Dis, 2020, Apr; 11(4): 274 PMID: 32332697
- D Jarmuzek, .et al. Phototransformations of pitavastatin - The inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, J Photochem Photobiol A Chem, 2019, November
- Marwan Ibrahim Abdullah, .et al. Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells, Sci Rep, 2017, 7: 8090 PMID: 28808351
Biological Activity
Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis.
Targets
| cholesterol esters | ||||
| In vitro | DMSO | 46 mg/mL (52.21 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.35 mL | 56.75 mL | 113.51 mL |
| 0.5 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 1 mM | 1.14 mL | 5.68 mL | 11.35 mL |
| 5 mM | 0.23 mL | 1.14 mL | 2.27 mL |
*The above data is based on the productmolecular weight 880.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10737 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 147526-32-7 |
| Formula | (C25H23FNO4)2.Ca |
| M. Wt | 880.98 |
| Purity | >98% |
| Synonyms | Livalo |
| SMILES | C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[[email protected]@H](O)C[[email protected]@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[[email protected]@H](O)C[[email protected]@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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