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- Mei Zheng, .et al. CXCL12 inhibits hair growth through CXCR4, Biomed Pharmacother, 2022, Jun;150:112996 PMID: 35462338
- Asiedu KO, .et al. Bone marrow cell homing to sites of acute tibial fracture: 89Zr-oxine cell labeling with positron emission tomographic imaging in a mouse model, EJNMMI Res, 2018, Dec 13;8(1):109 PMID: 30547233
- Kingsley O. Asiedu, .et al. Bone marrow cell trafficking analyzed by 89Zr-oxine positron emission tomography in a murine transplantation model, Clin Cancer Res, 2017, Jun 1; 23(11): 2759-2768 PMID: 27965305
Biological Activity
Plerixafor is an immunostimulant used to multiply hematopoietic stem cells and it is a chemokine receptor-4 antagonist for mobilization of hematopoietic stem cells for transplantation.
Targets
| CXCL12-mediated chemotaxis (Cell-free assay) | CXCR4 (Cell-free assay) | |||
| 5.7 nM | 44 nM |
| In vitro (25°C) | DMSO | Insoluble | |
| Water | 91 mg/mL (114.54 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | Saline | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.59 mL | 62.93 mL | 125.87 mL |
| 0.5 mM | 2.52 mL | 12.59 mL | 25.17 mL |
| 1 mM | 1.26 mL | 6.29 mL | 12.59 mL |
| 5 mM | 0.25 mL | 1.26 mL | 2.52 mL |
*The above data is based on the productmolecular weight 794.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10913 |
|---|---|
| Actions | Antagonist |
| CAS No. | 155148-31-5 |
| Formula | C28H54N8.8HCl |
| M. Wt | 794.5 |
| Purity | >98% |
| Synonyms | DB06809, AMD3100, Mozobil |
| SMILES | C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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