Polymyxin B is an antibiotic that primarily targets Gram-negative bacteria by binding with high affinity to lipopolysaccharides (LPS) in the bacterial cell wall. This binding disrupts membrane integrity, leading to increased permeability and ultimately inducing bacterial cell death. Polymyxin B is extensively utilized in research related to endotoxemia due to its ability to neutralize endotoxins and mitigate their harmful effects.
Polymyxin B is an antibiotic that primarily targets Gram-negative bacteria by binding with high affinity to lipopolysaccharides (LPS) in the bacterial cell wall. This binding disrupts membrane integrity, leading to increased permeability and ultimately inducing bacterial cell death. Polymyxin B is extensively utilized in research related to endotoxemia due to its ability to neutralize endotoxins and mitigate their harmful effects.
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