Fig. 1 · Structure
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Propargyl-PEG1-acid
PROTAC Linkers
Propargyl-PEG1-acid is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of BTK-CRBN PROTACs, specifically enhancing the degradation of Bruton’s Tyrosine Kinase (BTK), as well as other key proteins such as CSK, LYN, and LAT2, when utilized at concentrations of 10 μM. Featuring an alkyne functional group, Propargyl-PEG1-acid enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it an essential tool for researchers developing targeted protein degradation strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 55683-37-9 |
| Applications | PROTAC Linkers |
| Formula | C6H8O3 |
| Molecular Weight | 128.13 |
| SMILES | O=C(O)CCOCC#C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.