Propargyl-PEG1-acid is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of BTK-CRBN PROTACs, specifically enhancing the degradation of Bruton’s Tyrosine Kinase (BTK), as well as other key proteins such as CSK, LYN, and LAT2, when utilized at concentrations of 10 μM. Featuring an alkyne functional group, Propargyl-PEG1-acid enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it an essential tool for researchers developing targeted protein degradation strategies.
Propargyl-PEG1-acid is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of BTK-CRBN PROTACs, specifically enhancing the degradation of Bruton’s Tyrosine Kinase (BTK), as well as other key proteins such as CSK, LYN, and LAT2, when utilized at concentrations of 10 μM. Featuring an alkyne functional group, Propargyl-PEG1-acid enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it an essential tool for researchers developing targeted protein degradation strategies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
