Propargyl-PEG3-acid is a versatile non-cleavable linker designed for antibody-drug conjugates (ADCs) and PEG-based PROTAC applications. Its structure includes a three-unit polyethylene glycol (PEG) moiety and an alkyne group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This reagent is key in the synthesis of advanced bioconjugates, such as 6-OHDA-PEG3-yne, combining the bioactivity of 6-OHDA with the stability of the linker for targeted therapeutic applications.
Propargyl-PEG3-acid is a versatile non-cleavable linker designed for antibody-drug conjugates (ADCs) and PEG-based PROTAC applications. Its structure includes a three-unit polyethylene glycol (PEG) moiety and an alkyne group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This reagent is key in the synthesis of advanced bioconjugates, such as 6-OHDA-PEG3-yne, combining the bioactivity of 6-OHDA with the stability of the linker for targeted therapeutic applications.
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