Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
HO-PEG10-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enabling targeted protein degradation and modulation of cellular pathways. Its hydrophilic nature enhances solubility and biocompatibility, making it suitable for various research applications in drug discovery and targeted therapeutics. -
PROTAC Linker
3-Boc-aminomethylazetidine is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the targeting and degradation of specific proteins by linking E3 ligases to the desired protein targets, thus enabling selective modulation of protein levels. It is a valuable reagent for researchers studying targeted protein degradation and molecular interventions in various biological pathways. -
PROTAC Linker
((4-Bromobutoxy)methyl)benzene serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of targeted protein degradation by linking a specific ligand to an E3 ligase, thereby enabling the selective removal of target proteins. It is valuable for researchers investigating targeted protein modulation and degradation pathways in various biological contexts. -
PROTAC Linker
Boc-C15-COOH is a linker designed for PROTAC (Proteolysis Targeting Chimeras) applications, facilitating the development of novel targeted protein degradation strategies. This compound enhances the specificity and efficacy of PROTACs by connecting target proteins to E3 ligases, leading to selective ubiquitination and subsequent proteasomal degradation. It is particularly useful in research focused on delineating protein function and developing therapeutic agents in cancer and other diseases through targeted protein modulation. -
PROTAC Linker
tert-Butyl 3-(piperidin-4-yloxy)azetidine-1-carboxylate hydrochloride is a versatile PROTAC linker designed for the development of functional proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins within cellular systems, enabling studies on protein function and regulation. It serves as a crucial component in the synthesis of PROTACs, aiding in the advancement of targeted protein degradation research. -
PROTAC Linker
tert-Butyl (8-iodooctyl)carbamate serves as a PROTAC linker, facilitating the assembly of bifunctional molecules designed to target specific proteins for degradation. Its structural properties enhance the bioactivity of PROTAC compounds by improving cellular uptake and target specificity. This reagent is essential for researchers aiming to develop innovative protein degradation strategies in therapeutic and biochemical studies. -
PROTAC Linker
tert-Butyl 3-(aminomethyl)azetidine-1-carboxylate hydrochloride serves as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound is essential for creating bifunctional molecules that selectively degrade target proteins via the ubiquitin-proteasome system. Its efficacy in research applications includes enhancing targeted protein degradation for therapeutic purposes in cancer and other diseases. -
PROTAC Linker
1,6-Dichlorohexane is a PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). It plays a crucial role in enabling targeted protein degradation by linking E3 ligases to specific target proteins. This compound is essential for researchers investigating targeted therapeutics and the modulation of protein activity in cell biology studies. -
PROTAC Linker
(4-(3-Methoxy-3-oxopropyl)phenyl)boronic acid is a PROTAC (Proteolysis Targeting Chimera) linker that facilitates targeted protein degradation. This compound is crucial for the synthesis of PROTACs, enabling researchers to selectively remove unwanted proteins from cells. Its unique structure allows for effective engagement with E3 ubiquitin ligases and target proteins, making it a valuable tool in drug discovery, particularly in studies focused on therapeutic interventions for cancer and other diseases. -
PROTAC Linker
Methyl N-Boc-4-piperidinepropionate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound features a N-Boc protecting group and a piperidine moiety, enabling effective conjugation to E3 ligases and target proteins. Its utilization in PROTAC design supports studies in targeted protein degradation and offers potential applications in therapeutic development and chemical biology research. -
PROTAC Linker
2-(4-(4-Aminophenyl)piperazin-1-yl)ethanol is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its structure facilitates targeted protein degradation, making it valuable in the development of therapeutic compounds. This linker plays a crucial role in advancing research aimed at understanding protein dynamics and developing novel strategies for cancer treatment and other diseases. -
PROTAC Linker
Methyl 7-aminoheptanoate hydrochloride is a PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation, enabling specific modulation of protein levels within cellular systems. Its application in research contributes to advancements in drug discovery and therapeutic development by enabling the precise regulation of protein activity. -
PROTAC Linker
HOCH2-Cyclobutane-CH2COOMe is a versatile PROTAC linker that facilitates the creation of targeted protein degradation bioconjugates. This compound aids in the design of PROTACs (proteolysis-targeting chimeras) by connecting a target protein ligand to an E3 ligase recruitor, enhancing the efficiency of selective protein degradation. Its unique cyclobutane structure contributes to improved stability and cell permeability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
Methyl 2-cyanocyclopropanecarboxylate is a PROTAC linker that facilitates the design and synthesis of PROTAC molecules. Its unique structure allows for modular assembly, enabling targeted protein degradation via the ubiquitin-proteasome system. This compound is particularly useful in drug discovery and development for therapeutic applications that involve modulating protein levels in cellular systems. -
PROTAC Linker
tert-Butyl (2-(2-(methylamino)ethoxy)ethyl)carbamate is a PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, facilitating the targeted degradation of specific proteins within cells. Its effective incorporation enhances the design of molecular probes and therapeutic agents in drug discovery applications. -
PROTAC Linker
10-((((9h-Fluoren-9-yl)methoxy)carbonyl)amino)decanoic acid serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances target protein degradation by connecting an E3 ligase ligand to a protein of interest, enabling the efficient ubiquitination and subsequent proteasomal degradation. Its utility in chemical biology aids in the study of protein dynamics and targeted protein degradation applications in drug discovery. -
PROTAC Linker
Ethyl but-3-ynoate is a versatile PROTAC linker employed in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation, thus providing a valuable tool in the study of protein function and therapeutic development. Its unique structure enhances the pharmacological properties of PROTACs, making it an essential building block in chemical biology research. -
PROTAC Linkers
m-PEG7-Br is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and stability of PROTACs, facilitating the development of biopharmaceuticals that regulate target protein degradation. Its application in research includes the optimization of PROTAC structures for improved efficacy in targeted protein modulation. -
PROTAC Linker
4-Boc-(trans)-Cyclohexanediamine-2-ethyl acetate serves as a PROTAC linker, facilitating the development of protein degradation agents. This compound enables the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent proteasomal degradation. It is valuable in the synthesis of PROTACs for targeted protein modulation in various biological research applications. -
PROTAC Linker
Pent-4-yn-1-amine is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its alkyne functionality facilitates the formation of stable linkers essential for targeted protein degradation applications. This compound is instrumental in advancing research in targeted therapeutics and protein modulation studies. -
PROTAC Linker
tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by promoting their ubiquitination and subsequent proteasomal degradation. Its application is essential in drug discovery and development for tackling previously undruggable targets in cancer and other diseases. -
PROTAC Linker
rel-(1S,2R)-2-(((tert-butoxycarbonyl)amino)methyl)cyclopropane-1-carboxylic acid serves as a PROTAC linker, facilitating the targeted degradation of proteins through the ubiquitin-proteasome pathway. This compound is essential for the construction of PROTACs, enabling researchers to modulate protein levels and examine cellular processes. Its structural attributes promote efficient and selective engagement with target proteins, making it a valuable tool in chemical biology and therapeutic development. -
PROTAC Linker
Benzyl (piperidin-4-ylmethyl)carbamate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases to target proteins, thereby promoting their selective degradation. It is essential for applications in targeted protein degradation research, advancing the development of novel therapeutics. -
PROTAC Linker
Methyl 4-(aminomethyl)bicyclo[2.2.2]octane-1-carboxylate is a PROTAC linker that facilitates targeted protein degradation through the construction of PROTAC molecules. This compound serves as a versatile building block for synthesizing heterobifunctional compounds, enabling the selective recruitment of E3 ligases to specific target proteins. It is essential for research applications focused on elucidating protein functions and developing therapeutics that harness the power of the ubiquitin-proteasome system. -
PROTAC Linker
p-Bromophenoxyaceticacid serves as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the selective degradation of target proteins, making it a valuable tool in drug discovery and development. Its application in PROTAC synthesis allows researchers to explore innovative therapeutic strategies for modulating protein levels in various biological contexts. -
PROTAC Linker
tert-Butyl (2-(2-iodoethoxy)ethyl)carbamate functions as a PROTAC linker, enabling the development of proteolysis-targeting chimera (PROTAC) molecules for targeted protein degradation. Its structure facilitates the conjugation of protein ligands to E3 ligases, promoting ubiquitination and subsequent proteasomal degradation of specific proteins. This compound is crucial for researchers focusing on protein regulation, therapeutic discovery, and drug development for various diseases. -
PROTAC Linker
4-((tert-Butoxycarbonyl)(methyl)amino)butanoic acid serves as a versatile PROTAC linker, critical for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the selective degradation of proteins within cellular pathways. It is valuable in research applications focused on protein modulation and therapeutic development in cancer and neurodegenerative diseases. -
PROTAC Linker
tert-Butyl 3-(prop-2-yn-1-yloxy)azetidine-1-carboxylate serves as a PROTAC linker, facilitating targeted protein degradation through the formation of PROTACs. This compound allows for the selective modulation of protein levels in cellular systems, making it a valuable tool in drug discovery and research applications aimed at studying protein function and therapeutic intervention. Its unique structure enables efficient conjugation to ligands and E3 ligases, thereby enhancing the potency of PROTAC molecules. -
PROTAC Linker
1,15-Pentadecanediol is a versatile PROTAC linker designed to facilitate the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound exhibits favorable solubility and stability characteristics, enhancing the efficiency of targeted protein degradation studies. Its application in research enables the development of novel therapeutic strategies by allowing precise modulation of protein levels within cellular systems. -
PROTAC Linkers
Biotin-C5-amino-C5-amino is a versatile PROTAC linker featuring an alkyl chain structure designed for efficient PROTAC synthesis. This compound facilitates the targeted degradation of proteins by linking E3 ligases to the target protein, enhancing the specificity and efficacy of the degradation process. It is essential for researchers developing novel protein degradation strategies in drug discovery and therapeutic applications. -
PROTAC Linker
Tert-butyl (4-(hydroxymethyl)benzyl)(methyl)carbamate serves as a valuable PROTAC linker, facilitating the design and synthesis of PROTAC molecules. Its structural attributes enhance the efficiency of target protein degradation through the ubiquitin-proteasome pathway. This compound is essential for researchers exploring targeted protein degradation mechanisms and the development of innovative therapeutic strategies. -
PROTAC Linker
tert-Butyl N-({3-formylbicyclo[1.1.1]pentan-1-yl}methyl)carbamate functions as a linker in PROTAC (Proteolysis Targeting Chimeras) technology. This compound facilitates the development of bifunctional molecules that induce the ubiquitination and subsequent degradation of target proteins within cells. Its application in chemical biology enables the selective modulation of protein levels, making it valuable for research in targeted protein degradation and therapeutic development. -
PROTAC Linker
Carbobenzoxy-4-aminobutyric acid serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural properties enable the effective recruitment of E3 ligases and the targeted degradation of specific proteins, making it valuable for studies in targeted protein modulation and therapeutic development. This compound supports research applications in drug discovery and the mechanistic understanding of protein regulation. -
PROTAC Linker
14-Bromotetradecanoic acid serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of bifunctional molecules that can induce targeted protein degradation. Its effective incorporation into PROTAC constructs supports research in targeted therapy and drug discovery, enhancing the potential for selective protein modulation. -
PROTAC Linker
Tos-PEG3-Bn is a PROTAC linker designed for the efficient synthesis of PROTAC molecules. This compound features a hydrophilic PEG spacer, enhancing solubility and bioavailability. Tos-PEG3-Bn is utilized in drug discovery research, particularly in the development of targeted protein degradation strategies. -
PROTAC Linker
4-[2-(Trimethylsilyl)ethynyl]benzaldehyde is a versatile PROTAC linker facilitating the construction of PROTAC (proteolysis-targeting chimeras) molecules. It plays a crucial role in modular drug design by connecting various protein ligands to E3 ligases, thereby enabling targeted degradation of specific proteins within cellular environments. This compound is essential for researchers focused on therapeutic strategies in the field of targeted protein degradation and drug discovery. -
PROTAC Linker
12-Amino-1-dodecanol serves as a versatile PROTAC linker, facilitating the design and synthesis of PROTACs for targeted protein degradation. It enhances the stability and efficacy of conjugated compounds, enabling researchers to explore novel therapeutic strategies in disease models. This reagent is essential for studies focused on selective protein modulation and the development of innovative treatments. -
PROTAC Linkers
Biotin-PEG8-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of biotin to the PROTAC structure, enhancing cellular uptake and target specificity. Its key biological activity lies in promoting targeted protein degradation, making it a valuable tool in research applications focused on proteomics and drug discovery. -
PROTAC Linker
2-(2-(2-(tert-Butoxy)-2-oxoethoxy)ethoxy)acetic acid functions as a PROTAC linker, facilitating the conjugation of target proteins in proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the development of novel therapeutics that aim to utilize the ubiquitin-proteasome system for targeted protein degradation. Its use in research applications enhances the efficacy of PROTACs, allowing for specific modulation of protein levels in various biological contexts. -
PROTAC Linker
5-((tert-Butyldimethylsilyl)oxy)pentan-1-ol serves as a PROTAC linker, playing a crucial role in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of innovative therapeutic agents by enabling the targeted degradation of specific proteins within cells. Its ability to enhance cellular uptake and optimize pharmacokinetic properties makes it valuable for research applications focusing on targeted protein degradation and drug development. -
PROTAC Linker
3-Iodopropionic acid is a specialized PROTAC linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective engagement of E3 ligases and protein targets, enabling targeted protein degradation. Its incorporation in PROTAC design supports research in protein modulation and therapeutic applications in various diseases, offering a valuable tool for discovery in chemical biology. -
PROTAC Linker
tert-Butyl (6-oxospiro[3.3]heptan-2-yl)carbamate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the conjugation of target proteins, enhancing selective degradation pathways. Its unique structure facilitates the development of novel therapeutic strategies in chemical biology and drug discovery applications. -
PROTAC Linker
Fmoc-Gly-NH-CH2-O-CH2-Cbz is a PROTAC linker designed for targeted protein degradation via the ubiquitin-proteasome system. This compound facilitates the construction of bifunctional molecules, enabling selective degradation of target proteins. It is particularly useful in the synthesis of derivatives such as Deruxtecan, contributing to advancements in therapeutic development for various diseases. -
PROTAC Linker
6-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)hexanoic acid functions as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins, offering significant potential in targeted protein modulation and therapeutic applications. Its structure allows for effective integration into various PROTAC constructs, making it an essential reagent for researchers in drug discovery and development efforts. -
PROTAC Linker
Tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate serves as a PROTAC linker, facilitating targeted protein degradation through the recruitment of E3 ligases. This compound is instrumental in the development of PROTACs, enabling precise modulation of protein levels within cellular environments. Its unique structural properties enhance the stability and efficacy of PROTAC formulations, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
2-(4-(tert-Butoxycarbonyl)-2-oxopiperazin-1-yl)acetic acid serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs by enabling the selective degradation of target proteins, thus advancing research in targeted protein degradation and therapeutic strategies in various diseases. It is essential for studies focused on protein modulation and cellular processes. -
PROTAC Linkers
Biotin-C10-NHS Ester is an alkyl/ether-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of biotin to target proteins, enabling the recruitment of an E3 ligase for targeted degradation. Its primary applications include the development of targeted protein degradation strategies and the study of protein dynamics in cellular pathways. -
PROTAC Linker
2-(trans-3-((tert-Butoxycarbonyl)amino)cyclobutyl)acetic acid serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound is crucial in the synthesis of PROTACs, enabling selective modulation of protein function through the ubiquitin-proteasome system. Its structure is designed to optimize binding interactions, making it an essential tool in chemical biology and therapeutic research applications. -
PROTAC Linker
Benzyl (4-aminobutyl)carbamate hydrochloride is utilized as a PROTAC (Proteolysis Targeting Chimera) linker, facilitating the development of targeted protein degradation strategies. This compound plays a crucial role in the synthesis of PROTACs, enabling the selective degradation of specific proteins within cellular contexts. It is particularly relevant in research applications focused on targeted therapies in cancer and other diseases associated with protein dysregulation. -
PROTAC Linker
Benzyl 4-(aminomethyl)piperidine-1-carboxylate serves as a PROTAC linker, facilitating the development of proteolysis targeting chimeras (PROTACs). This compound is integral in connecting target proteins to E3 ligases, enabling selective degradation pathways in cellular systems. Its unique structural properties enhance the efficacy of PROTAC design and optimization in chemical biology research.
