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- Anna L Koessinger, .et al. Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics, Cell Death Differ, 2022, Apr 26 PMID: 35473984
- Florian J Bock, .et al. Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death, Nat Commun, 2021, Nov 12;12(1):6572 PMID: 34772930
- Davide Pradella, .et al. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis, Nat Commun, 2021, 12: 4872 PMID: 34381052
- Haschka MD, .et al. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment, Cell Death Differ, 2020, Feb 3 PMID: 32015503
Biological Activity
Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
Targets
Caspase-1 | Caspase-3 | Caspase-8 | Caspase-9 | |
25 nM-400 nM | 25 nM-400 nM | 25 nM-400 nM | 25 nM-400 nM |
In vitro | DMSO | 94 mg/mL (183.06 mM) | |
Water | Insoluble | ||
Ethanol | 94 mg/mL (183.06 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.47 mL | 97.37 mL | 194.75 mL |
0.5 mM | 3.89 mL | 19.47 mL | 38.95 mL |
1 mM | 1.95 mL | 9.74 mL | 19.47 mL |
5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
*The above data is based on the productmolecular weight 513.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A14915 |
---|---|
Actions | Inhibitor |
CAS No. | 1135695-98-5 |
Formula | C26H25F2N3O6 |
M. Wt | 513.49 |
Purity | >98% |
SMILES | CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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