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Q-VD-OPh hydrate

Q-VD-OPh hydrate

Name: Q-VD-OPh hydrate
Brand: Adooq Bioscience
SKU: A14915
Rating: 100 (1 reviews)

Catalog No.: A14915

Caspase inhibitor

Product Citations (1)

Q-VD-OPh hydrate Chemical Structure

CAS NO. 1135695-98-5

Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$150.00
25 mg	$240.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Q-VD-OPh hydrate

Haschka MD, .et al. MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment, Cell Death Differ, 2020, Feb 3 PMID: 32015503

Biological Activity

Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).

Targets

Caspase-1	Caspase-3	Caspase-8	Caspase-9
25 nM-400 nM	25 nM-400 nM	25 nM-400 nM	25 nM-400 nM

Solubility *

In vitro	DMSO	94 mg/mL (183.06 mM)
	Water	Insoluble
	Ethanol	94 mg/mL (183.06 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.47 mL	97.37 mL	194.75 mL
0.5 mM	3.89 mL	19.47 mL	38.95 mL
1 mM	1.95 mL	9.74 mL	19.47 mL
5 mM	0.39 mL	1.95 mL	3.89 mL

*The above data is based on the productmolecular weight 513.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A14915
Actions	Inhibitor
CAS No.	1135695-98-5
Formula	C26H25F2N3O6
M. Wt	513.49
Purity	>98%
SMILES	CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.