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Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
Targets
| Caspase-1 | Caspase-3 | Caspase-8 | Caspase-9 | |
| 25 nM-400 nM | 25 nM-400 nM | 25 nM-400 nM | 25 nM-400 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.47 mL | 97.37 mL | 194.75 mL |
| 0.5 mM | 3.89 mL | 19.47 mL | 38.95 mL |
| 1 mM | 1.95 mL | 9.74 mL | 19.47 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
*The above data is based on the productmolecular weight 513.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A14915 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 513.49 |
| Formula | C26H25F2N3O6 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1135695-98-5 |
| Synonyms | N/A |
| SMILES | CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2 |
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