(R)-Niguldipine is a calcium channel antagonist that effectively blocks calcium channels, leading to vasodilation by reducing the influx of calcium ions across cell membranes. It demonstrates potent inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, with a pID50 of 9.93, and displays high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10). (R)-Niguldipine also significantly lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55), making it a valuable compound for research in cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias.
(R)-Niguldipine is a calcium channel antagonist that effectively blocks calcium channels, leading to vasodilation by reducing the influx of calcium ions across cell membranes. It demonstrates potent inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, with a pID50 of 9.93, and displays high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10). (R)-Niguldipine also significantly lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55), making it a valuable compound for research in cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias.
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