(Rac)-OSMI-1 is a racemic mixture of OSMI-1, a potent inhibitor of O-GlcNAc transferase (OGT) that exhibits an IC50 value of 2.7 μM. This compound effectively inhibits O-linked N-acetylglucosamine (O-GlcNAcylation) in various mammalian cell lines, while not significantly affecting cell surface N- or O-linked glycans. Its application spans diverse studies in cellular signaling and glycosylation modifications, making it a valuable tool for research into OGT-related biological processes.
(Rac)-OSMI-1 is a racemic mixture of OSMI-1, a potent inhibitor of O-GlcNAc transferase (OGT) that exhibits an IC50 value of 2.7 μM. This compound effectively inhibits O-linked N-acetylglucosamine (O-GlcNAcylation) in various mammalian cell lines, while not significantly affecting cell surface N- or O-linked glycans. Its application spans diverse studies in cellular signaling and glycosylation modifications, making it a valuable tool for research into OGT-related biological processes.
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