RAI-20 is a potent orally active dual inhibitor of JAK1 and JAK2, demonstrating IC50 values of 15.1 nM and 22.7 nM, respectively. This compound features favorable pharmacokinetic characteristics, including enhanced plasma stability and extended systemic exposure. In preclinical studies using a collagen-induced arthritis rat model, RAI-20 exhibited significant anti-inflammatory and anti-arthritic effects, effectively decreasing paw swelling volume and overall arthritis index. RAI-20 serves as a valuable tool for investigating the mechanisms underlying rheumatoid arthritis pathology.
RAI-20 is a potent orally active dual inhibitor of JAK1 and JAK2, demonstrating IC50 values of 15.1 nM and 22.7 nM, respectively. This compound features favorable pharmacokinetic characteristics, including enhanced plasma stability and extended systemic exposure. In preclinical studies using a collagen-induced arthritis rat model, RAI-20 exhibited significant anti-inflammatory and anti-arthritic effects, effectively decreasing paw swelling volume and overall arthritis index. RAI-20 serves as a valuable tool for investigating the mechanisms underlying rheumatoid arthritis pathology.
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