Total item
Cart Subtotal
$0.00 Biological Activity
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature.
Targets
| Target | Value |
|---|---|
| RET | IC50: 1.5nM |
| Raf-1 | IC50: 2.5nM |
| VEGFR2 | IC50: 4.2nM |
| Kit | IC50: 7nM |
| VEGFR1 | IC50: 13nM |
| B-Raf(V600E) | IC50: 19nM |
| PDGFRβ | IC50: 22nM |
| B-Raf | IC50: 28nM |
| VEGFR3 | IC50: 46nM |
| FGFR1 | IC50: 202nM |
| Tie-2 | IC50: 311nM |
| In vitro (25°C) | DMSO | 97 mg/mL (200.9 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.71 mL | 103.56 mL | 207.13 mL |
| 0.5 mM | 4.14 mL | 20.71 mL | 41.43 mL |
| 1 mM | 2.07 mL | 10.36 mL | 20.71 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
*The above data is based on the productmolecular weight 482.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10250 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 482.8 |
| Formula | C21H15ClF4N4O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 755037-03-7 |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
PLX7904
PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melan…
Imatinib (Gleevec)
Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor.
Kaempferol
Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expressi…
E7080 (Lenvatinib)
E7080 is a multi-kinase inhibitor that inhibits both VEGFR2 and VEGFR3 kinases.
CP-547632
CP-547632 is a novel, potent vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor
RO5126766 (CH5126766)
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) wi…
E-3810
E-3810 is a potent and selective dual inhibitor of VEGF and FGF receptors with IC50 values of 7 nM, 25 nM, 10 nM, 17.5 nM and 82.5 nM for VE…
RAF265 (CHIR-265)
RAF265 (CHIR-265) is an oral, highly selective RAF and VEGFR kinase inhibitor, which is to control or normalize VEGFR-2 along with the inhib…
Keywords:buy Regorafenib (BAY 73-4506) | Regorafenib (BAY 73-4506) Supplier | purchase Regorafenib (BAY 73-4506) | Regorafenib (BAY 73-4506) cost | Regorafenib (BAY 73-4506) manufacturer | order Regorafenib (BAY 73-4506) | Regorafenib (BAY 73-4506) distributor | buy 755037-03-7| 755037-03-7 Supplier | purchase 755037-03-7 | 755037-03-7 cost | 755037-03-7 manufacturer | order 755037-03-7 | 755037-03-7 distributor
Adooq Quality Guarantee
We promise all products perform as described.