RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).
Xu H, .et al. , Cancer Lett, 2020, Mar 1;472:151-164 PMID: 31846689
Biological Activity
Description
RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).
Targets
Target
Value
Cell Research
Cell Line
Type
Value
Description
References
Product Information
Catalog Num
A11762
Formula
C17H13N5
Molecular Weight
287.32
CAS Number
446859-33-2
SMILES
CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
Synonyms
E-616452, SJN 2511, ALK 5 inhibitor
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
49 mg/mL (170.54 mM)
Water
Insoluble
Ethanol
Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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