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- Wojciech J Szlachcic, .et al. SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis, iScience, 2022, Jul 15;25(7) PMID: 35756892
- Xu H, .et al. Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFβ1/p-Smad2/3 signaling, Cancer Lett, 2020, Mar 1;472:151-164 PMID: 31846689
Biological Activity
RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).
Targets
| TGFβR1(ALK5) (Cell-free assay) | ||||
| 4 nM |
| In vitro | DMSO | 49 mg/mL (170.54 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.8 mL | 174.02 mL | 348.04 mL |
| 0.5 mM | 6.96 mL | 34.8 mL | 69.61 mL |
| 1 mM | 3.48 mL | 17.4 mL | 34.8 mL |
| 5 mM | 0.7 mL | 3.48 mL | 6.96 mL |
*The above data is based on the productmolecular weight 287.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11762 |
|---|---|
| CAS No. | 446859-33-2 |
| Formula | C17H13N5 |
| M. Wt | 287.32 |
| Purity | >98% |
| Synonyms | E-616452, SJN 2511, ALK 5 inhibitor |
| SMILES | CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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