RepSox (SJN 2511)

Catalog No.: A11762

RepSox (SJN 2511)

RepSox (SJN 2511) Chemical Structure

CAS NO. 446859-33-2

RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$200.00
50 mg
$350.00
100 mg
$600.00
10mM * 1mL in DMSO
$65.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Xu H, .et al. Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFβ1/p-Smad2/3 signaling, Cancer Lett, 2020, Mar 1;472:151-164 PMID: 31846689

Biological Activity

RepSox (SJN 2511) is a selective inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively).
Targets
TGFβR1(ALK5) (Cell-free assay)
4 nM
In vitro DMSO 49 mg/mL (170.54 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.8 mL 174.02 mL 348.04 mL
0.5 mM 6.96 mL 34.8 mL 69.61 mL
1 mM 3.48 mL 17.4 mL 34.8 mL
5 mM 0.7 mL 3.48 mL 6.96 mL

*The above data is based on the productmolecular weight 287.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11762
CAS No. 446859-33-2
Formula C17H13N5
M. Wt 287.32
Solubility DMSO
Purity >98%
Synonyms E-616452, SJN 2511, ALK 5 inhibitor
SMILES CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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