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$0.00 - Matt D Johansen, .et al. Rifabutin is bactericidal against intracellular and extracellular forms of Mycobacterium abscessus, Antimicrob Agents Chemother, 2020, Aug 17;AAC.00363-20 PMID: 32816730
- Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
- Dinah Binte Aziz, .et al. Rifabutin Is Active against Mycobacterium abscessus Complex, Antimicrob Agents Chemother, 2017, Jun; 61(6): e00155-17 PMID: 28396540
Biological Activity
Rifabutin is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria.
| In vitro | DMSO | 60 mg/mL (70.83 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 40 mg/mL (47.22 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.81 mL | 59.03 mL | 118.06 mL |
| 0.5 mM | 2.36 mL | 11.81 mL | 23.61 mL |
| 1 mM | 1.18 mL | 5.9 mL | 11.81 mL |
| 5 mM | 0.24 mL | 1.18 mL | 2.36 mL |
*The above data is based on the productmolecular weight 847.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10790 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 847.0 |
| Formula | C46H62N4O11 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 72559-06-9 |
| Synonyms | Mycobutin |
| SMILES | C[[email protected]]1/C=C/C=C(\C(=O)NC2=C3C(=NC4(N3)CCN(CC4)CC(C)C)C5=C6C(=C(C(=C5C2=O)O)C)O[[email protected]@](C6=O)(O/C=C/[[email protected]@H]([[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H]([[email protected]@H]([[email protected]]1O)C)O)C)OC(=O)C)C)OC)C)/C |
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