Rifaquizinone is a hybrid antibiotic that combines the mechanisms of Rifamycin and Quinolone. It effectively inhibits wild-type Staphylococcus aureus RNA polymerase, exhibiting an IC50 value of 34 nM. Rifaquizinone demonstrates potent antibacterial activity against S. aureus infections, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.5 μg/mL across 300 clinical isolates of staphylococci and streptococci, making it a valuable tool for antibiotic research and investigation into resistance mechanisms.
Rifaquizinone is a hybrid antibiotic that combines the mechanisms of Rifamycin and Quinolone. It effectively inhibits wild-type Staphylococcus aureus RNA polymerase, exhibiting an IC50 value of 34 nM. Rifaquizinone demonstrates potent antibacterial activity against S. aureus infections, with minimum inhibitory concentrations (MICs) ranging from 0.008 to 0.5 μg/mL across 300 clinical isolates of staphylococci and streptococci, making it a valuable tool for antibiotic research and investigation into resistance mechanisms.
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