Ritlecitinib (malonate) is a selective, orally bioavailable, irreversible inhibitor of JAK3, exhibiting an IC50 of 33 nM. This compound effectively inactivates JAK3, thereby disrupting signaling pathways and downstream STAT phosphorylation triggered by common gamma chain cytokines, including IL-2 and IL-15. Ritlecitinib (malonate) is particularly useful for research into immune-related conditions, as it diminishes Th1/Th17 cell differentiation and function, and has shown efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis.
Ritlecitinib (malonate) is a selective, orally bioavailable, irreversible inhibitor of JAK3, exhibiting an IC50 of 33 nM. This compound effectively inactivates JAK3, thereby disrupting signaling pathways and downstream STAT phosphorylation triggered by common gamma chain cytokines, including IL-2 and IL-15. Ritlecitinib (malonate) is particularly useful for research into immune-related conditions, as it diminishes Th1/Th17 cell differentiation and function, and has shown efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis.
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