Ritlecitinib tosylate is a selective, orally active, irreversible covalent inhibitor of JAK3, exhibiting an IC50 value of 33 nM. It does not inhibit JAK1, JAK2, or TYK2, demonstrating a unique specificity for JAK3. This compound effectively interrupts signaling and downstream STAT phosphorylation induced by common gamma chain cytokines like IL-2 and IL-15. Ritlecitinib tosylate has been shown to inhibit Th1/Th17 cell differentiation and function, making it a valuable tool for research applications related to autoimmune diseases, with demonstrated efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis.
Ritlecitinib tosylate is a selective, orally active, irreversible covalent inhibitor of JAK3, exhibiting an IC50 value of 33 nM. It does not inhibit JAK1, JAK2, or TYK2, demonstrating a unique specificity for JAK3. This compound effectively interrupts signaling and downstream STAT phosphorylation induced by common gamma chain cytokines like IL-2 and IL-15. Ritlecitinib tosylate has been shown to inhibit Th1/Th17 cell differentiation and function, making it a valuable tool for research applications related to autoimmune diseases, with demonstrated efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis.
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