Ro 0437626

Catalog No.: A67909
P2X1 receptor antagonist
Ro 0437626 is a selective antagonist of the purinergic P2X1 receptor, exhibiting an IC50 value of 3 μM. It demonstrates low affinity for P2X2, P2X3, and P2X2/3 receptors, with IC50 values exceeding 100 μM. This compound is valuable for research applications involving the modulation of P2X1 receptor signaling pathways, contributing to studies in cardiovascular and pain research.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionRo 0437626 is a selective antagonist of the purinergic P2X1 receptor, exhibiting an IC50 value of 3 μM. It demonstrates low affinity for P2X2, P2X3, and P2X2/3 receptors, with IC50 values exceeding 100 μM. This compound is valuable for research applications involving the modulation of P2X1 receptor signaling pathways, contributing to studies in cardiovascular and pain research.
Product Information
Catalog NumA67909
FormulaC27H35N5O4S
Molecular Weight525.66
CAS Number134362-79-1
SMILESO=C(C1=NC2=CC=CC=C2N1)N[C@H](CC3=CSC=N3)C(N[C@@H](CC4CCCCC4)[C@@H](O)[C@H](C5CC5)O)=O
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