RO-3 is a potent orally active antagonist of the P2X3 and P2X2/3 receptors, exhibiting pIC50 values of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. This compound demonstrates selectivity for P2X3 and P2X2/3, with IC50 values exceeding 10 μM against all other functional P2X receptor homomultimers, including P2X1, P2X2, P2X4, P2X5, and P2X7. RO-3 is valuable for research focused on pain pathways and chronic pain conditions due to its specific receptor interactions.
RO-3 is a potent orally active antagonist of the P2X3 and P2X2/3 receptors, exhibiting pIC50 values of 5.9 and 7.0 for human homomultimeric P2X3 and heteromultimeric P2X2/3 receptors, respectively. This compound demonstrates selectivity for P2X3 and P2X2/3, with IC50 values exceeding 10 μM against all other functional P2X receptor homomultimers, including P2X1, P2X2, P2X4, P2X5, and P2X7. RO-3 is valuable for research focused on pain pathways and chronic pain conditions due to its specific receptor interactions.
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