ROCK-IN-9 is a selective inhibitor of Rho-associated protein kinase (ROCK). This compound exhibits cytotoxic effects in HepG2 cells with an IC50 value of 40.8 μM. Additionally, ROCK-IN-9 demonstrates favorable pharmacokinetic properties in murine models, indicating significant in vivo exposure and oral bioavailability at lower doses. Its profile makes it a valuable reagent for research focused on cancer biology and signaling pathways associated with ROCK inhibition.
ROCK-IN-9 is a selective inhibitor of Rho-associated protein kinase (ROCK). This compound exhibits cytotoxic effects in HepG2 cells with an IC50 value of 40.8 μM. Additionally, ROCK-IN-9 demonstrates favorable pharmacokinetic properties in murine models, indicating significant in vivo exposure and oral bioavailability at lower doses. Its profile makes it a valuable reagent for research focused on cancer biology and signaling pathways associated with ROCK inhibition.
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