ROCK2-IN-14 is a selective inhibitor of ROCK2, exhibiting an IC50 of 4.8 nM and 212-fold selectivity over ROCK1. This compound inhibits the ROCK2/S100A9 signaling pathway, leading to downregulation of S100A9 expression, inhibition of NM2 phosphorylation, and restoration of cytoskeletal abnormalities. It demonstrates significant anti-inflammatory effects, including the reduction of cytokines such as IgE, TNF-α, IL-6, and TSLP, and is effective in mitigating ear thickening in mouse models of atopic dermatitis. ROCK2-IN-14 is suitable for studies focused on inflammation and skin disorders.
ROCK2-IN-14 is a selective inhibitor of ROCK2, exhibiting an IC50 of 4.8 nM and 212-fold selectivity over ROCK1. This compound inhibits the ROCK2/S100A9 signaling pathway, leading to downregulation of S100A9 expression, inhibition of NM2 phosphorylation, and restoration of cytoskeletal abnormalities. It demonstrates significant anti-inflammatory effects, including the reduction of cytokines such as IgE, TNF-α, IL-6, and TSLP, and is effective in mitigating ear thickening in mouse models of atopic dermatitis. ROCK2-IN-14 is suitable for studies focused on inflammation and skin disorders.
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