RWJ 22108 is a bronchoselective calcium channel blocker that inhibits calcium influx in smooth muscle cells, demonstrating an IC50 value of 5.7 nM in the calcium-dependent contraction of canine bronchiolar smooth muscle. This compound is primarily utilized in research applications focused on respiratory physiology and the study of bronchial hyper-reactivity. Its specificity for bronchial tissues makes it a valuable tool in exploring mechanisms of airway relaxation and potential therapeutic interventions for respiratory disorders.
RWJ 22108 is a bronchoselective calcium channel blocker that inhibits calcium influx in smooth muscle cells, demonstrating an IC50 value of 5.7 nM in the calcium-dependent contraction of canine bronchiolar smooth muscle. This compound is primarily utilized in research applications focused on respiratory physiology and the study of bronchial hyper-reactivity. Its specificity for bronchial tissues makes it a valuable tool in exploring mechanisms of airway relaxation and potential therapeutic interventions for respiratory disorders.
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