S-22153 is a selective antagonist of the melatonin receptors MT1 and MT2, exhibiting high potency with EC50 values of 19 nM and 4.6 nM for hMT1 and hMT2, respectively. Its Ki values demonstrate strong binding affinity, measuring 8.6 nM for hMT1 in CHO cells and 16.3 nM in HEK cells, while exhibiting Ki values of 6.0 nM and 8.2 nM for hMT2 in the same cell lines. S-22153 is primarily utilized in research focusing on sleep regulation, circadian biology, and neuropharmacology.
S-22153 is a selective antagonist of the melatonin receptors MT1 and MT2, exhibiting high potency with EC50 values of 19 nM and 4.6 nM for hMT1 and hMT2, respectively. Its Ki values demonstrate strong binding affinity, measuring 8.6 nM for hMT1 in CHO cells and 16.3 nM in HEK cells, while exhibiting Ki values of 6.0 nM and 8.2 nM for hMT2 in the same cell lines. S-22153 is primarily utilized in research focusing on sleep regulation, circadian biology, and neuropharmacology.
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