S-312 is a calcium antagonist characterized by a bicyclic dihydrothienopyridine structure. This compound effectively relaxes helical strips of isolated rabbit arteries that have been pre-contracted with high potassium depolarization. S-312 acts as a competitive inhibitor of calcium-induced contractions in depolarized basilar and femoral arteries, and it also prolongs AV nodal conduction time in Langendorff-perfused isolated rabbit hearts. Additionally, S-312 demonstrates vasculoselectivity, particularly targeting cerebral vessels, making it a valuable tool for cardiovascular research applications.
S-312 is a calcium antagonist characterized by a bicyclic dihydrothienopyridine structure. This compound effectively relaxes helical strips of isolated rabbit arteries that have been pre-contracted with high potassium depolarization. S-312 acts as a competitive inhibitor of calcium-induced contractions in depolarized basilar and femoral arteries, and it also prolongs AV nodal conduction time in Langendorff-perfused isolated rabbit hearts. Additionally, S-312 demonstrates vasculoselectivity, particularly targeting cerebral vessels, making it a valuable tool for cardiovascular research applications.
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