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Biological Activity
(S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.28 mL | 86.41 mL | 172.83 mL |
| 0.5 mM | 3.46 mL | 17.28 mL | 34.57 mL |
| 1 mM | 1.73 mL | 8.64 mL | 17.28 mL |
| 5 mM | 0.35 mL | 1.73 mL | 3.46 mL |
*The above data is based on the productmolecular weight 578.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16323 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1189561-66-7 |
| Formula | C32H34O10 |
| M. Wt | 578.61 |
| Purity | >98% |
| Synonyms | (S)-(+)-Gossypol acetic acid |
| SMILES | CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C.CC(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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