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$0.00 Bcl-2 Family
| Catalog No. | Inhibitor Name | Bcl-2 | Bcl-B | Bcl-w | Bcl-xL | Mcl-1 | A1 | Bax | Other |
|---|---|---|---|---|---|---|---|---|---|
| A10255 | ABT-737 | **** | * | *** | *** | ||||
| A10022 | Navitoclax (ABT-263) | **** | **** | **** | ** | ** | |||
| A10665 | Obatoclax Mesylate | *** | |||||||
| A10955 | TW-37 | *** | * | *** | |||||
| A12500 | Venetoclax | **** | *** | **** | |||||
| A15004 | AT101 | ** | ** | *** | |||||
| A11448 | HA14-1 | * | |||||||
| A12823 | Sabutoclax | ** | ** | *** | ** | ||||
| A15545 | A-1210477 | **** | |||||||
| A14222 | UMI-77 | ** | |||||||
| A11988 | Gambogic Acid | * | * | **** | * | * | * | Caspase | |
| A12743 | BM-1074 | **** | **** | ||||||
| A13327 | WEHI-539 hydrochloride | **** | |||||||
| A15821 | BDA-366 | *** | |||||||
| A16061 | BH3I-1 | * | p53 | ||||||
| A16112 | A-1155463 | **** | |||||||
| A16190 | A-1331852 | **** | |||||||
| A16314 | Apogossypolone (ApoG2) |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
45 Item(s)
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ABT-737
Catalog No. A10255 Bcl-2 InhibitorABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60). Learn More -
ABT-199 (Venetoclax)
Catalog No. A12500 Bcl-2 inhibitorABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2. Learn More -
Sabutoclax
Catalog No. A12823 Bcl-2 inhibitorSabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. Learn More -
Bcl-2 Inhibitor
Catalog No. A13580 Bcl-2 InhibitorBcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively). Learn More -
BAM 7
Catalog No. A12907 Bax activatorBAM 7 binds the BAX trigger site with an EC50 ~ 3.3 μM as measured in a competitive FP assay using FITC-BIM SAHB and BAX. Learn More -
MIM1
Catalog No. A16315 Mcl-1 inhibitorMIM1 is a selective small molecule inhibitor of Mcl-1(IC50= 4.8 μM) that overcomes Mcl-1-dependent leukemia cell survival. Learn More -
A-1155463
Catalog No. A16112 BCL-XL inhibitorA-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM) Learn More -
Obatoclax mesylate (GX15-070)
Catalog No. A10665 Bcl-2 InhibitorBcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Learn More -
ABT-263 (Navitoclax)
Catalog No. A10022 Bcl-2 inhibitorABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). it maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.Learn More -
BTSA1
Catalog No. A16835 Bcl-2 modulatorBTSA1 is a pharmacologically optimized BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis. It effectively promotes apoptosis in leukemia cell lines and patient samples while sparing healthy cells. Learn More -
AZD5991
Catalog No. A16880 Mcl-1 inhibitorAZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay. Learn More -
A-385358
Catalog No. A17064 Bcl-XL inhibitorA-385358 is an inhibitor of Bcl-XL that enhances the in vitro cytotoxic activity of numerous chemotherapeutic agents (paclitaxel, etoposide, cisplatin, and doxorubicin) in several tumor cell lines. Learn More -
WEHI539
Catalog No. A13005 Bcl-XL inhibitorWEHI539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM. Learn More -
AZD-4320
Catalog No. A17171 Bcl-2/Bcl-XL inhibitorAZD-4320 is a BH3 mimetic and dual Bcl-2/Bcl-XL inhibitor. Learn More -
Maritoclax (Marinopyrrole A)
Catalog No. A17206 Mcl-1 inhibitorMarinopyrrole A, aslo known as Maritoclax, is a selective inhibitor of Mcl-1 with IC50 value of 10.1μM. Learn More -
MCL-1/BCL-2-IN-3
Catalog No. A18385 Mcl-1 and Bcl-2 dual inhibitorMCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively. Learn More -
MCL-1/BCL-2-IN-4
Catalog No. A18380 Mcl-1 and Bcl-2 dual inhibitorMCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor. Learn More -
ML311
Catalog No. A18364 Mcl-1/Bim interaction inhibitorML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction Learn More -
S55746
Catalog No. A18361 BCL-2 inhibitorS55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity. Learn More -
Bax-activator-106
Catalog No. A18406 Bax agonistBax-activator-106 is a specific Bax agonist. It acts by promoting Bax-dependent but not Bak-dependent apoptosis. Learn More -
BM 957
Catalog No. A18387 Bcl-2 and Bcl-xL inhibitorBM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM respectively. Learn More -
Jaceosidin
Catalog No. A12080 Jaceosidin is a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. Learn More -
AT-101
Catalog No. A15004 Bcl-2 InhibitorAT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM. Learn More -
UMI-77
Catalog No. A14222 Mcl-1 inhibitorUMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family. Learn More -
HA14-1
Catalog No. A11448 Bcl-2 inhibitorHA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2. Learn More -
A-1331852
Catalog No. A16190 BCL-XL inhibitorA-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML. Learn More -
AT101 acetic acid
Catalog No. A13578 pan Bcl-2 inhibitorAT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID Learn More -
TW-37
Catalog No. A10955 Bcl-2 inhibitorTW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1. Learn More -
BM-1074
Catalog No. A12743 Bcl-2/Bcl-xL inhibitorBM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM. Learn More -
(+)-Apogossypol
Catalog No. A16316 Bcl-2 family inhibitor(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM. Learn More -
(S)-Gossypol acetic acid
Catalog No. A16323 (S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM). Learn More -
Apogossypolone (ApoG2)
Catalog No. A16314 Bcl-2 inhibitorApogossypolone is a nonpeptidic small-molecule inhibitor of Bcl-2 with Learn More -
BH3I-1
Catalog No. A16061 Bcl-XL antagonistBH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL Learn More -
Acetate gossypol
Catalog No. A14795 Bcl-2 InhibitorAcetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic. Learn More -
BDA-366
Catalog No. A15821 Bcl-2 antagonistBDA-366 selectively inhibits BCL2, converting it to a cell death inducer. Learn More -
A-1210477
Catalog No. A15545 MCL-1 inhibitorA-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines. Learn More -
WEHI-539 hydrochloride
Catalog No. A13327 Bcl-xL inhibitorWEHI-539 hydrochloride is a small-molecule inhibitor of BCL-xL with IC50 value of 1.1 nM. Learn More -
Muristerone A
Catalog No. A15340 EcR agonistMuristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax. Learn More -
CID5721353
Catalog No. A16192 BCL6 inhibitorCID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor). Learn More -
Bax inhibitor peptide V5
Catalog No. A15337 Bax inhibitorBax inhibitor peptide V5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro. Learn More -
Gambogic acid
Catalog No. A11988 Bcl-2 inhibitorGambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively. Learn More -
Bax inhibitor peptide, negative control
Catalog No. A15338 Bax inhibitorBax inhibitor peptide, negative control, negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro. Learn More -
Pyridoclax (MR-29072)
Catalog No. A16380 Mcl-1 inhibitorPyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM. Learn More -
Bax inhibitor peptide P5
Catalog No. A15336 Bax inhibitorBax inhibitor peptide P5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro. Learn More -
Bax channel blocker
Catalog No. A15335 Bax channel blockerBax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM). Learn More
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