Bcl-2 Family

Catalog No.Inhibitor Name Bcl-2Bcl-BBcl-wBcl-xLMcl-1A1BaxOther
A10255ABT-737
****
*
***
***
A10022Navitoclax (ABT-263)
****
****
****
**
**
A10665Obatoclax Mesylate
***
A10955TW-37
***
*
***
A12500Venetoclax
****
***
****
A15004AT101
**
**
***
A11448HA14-1
*
A12823Sabutoclax
**
**
***
**
A15545A-1210477
****
A14222UMI-77
**
A11988Gambogic Acid
*
*
****
*
*
*
Caspase
A12743BM-1074
****
****
A13327WEHI-539 hydrochloride
****
A15821BDA-366
***
A16061BH3I-1
*
p53
A16112A-1155463
****
A16190A-1331852
****
A16314Apogossypolone (ApoG2)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. ABT-263 (Navitoclax)

    Catalog No. A10022
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    Bcl-2 inhibitor
    ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w).ABT-263 maintains a high affinity for Bcl-xL, Bcl-2, and Bcl-w, (Ki ≤1 nmol/L), but binds more weakly to Mcl-1 and A1.
    Learn More
  2. ABT-737

    Catalog No. A10255
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    Bcl-2 Inhibitor
    ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60). Learn More
  3. AZD5991

    Catalog No. A16880
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    Mcl-1 inhibitor
    AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay. Learn More
  4. WEHI539

    Catalog No. A13005
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    Bcl-XL inhibitor
    WEHI539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM. Learn More
  5. A-385358

    Catalog No. A17064
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    Bcl-XL inhibitor
    A-385358 is an inhibitor of Bcl-XL that enhances the in vitro cytotoxic activity of numerous chemotherapeutic agents (paclitaxel, etoposide, cisplatin, and doxorubicin) in several tumor cell lines. Learn More
  6. ABT-199 (Venetoclax)

    Catalog No. A12500
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    Bcl-2 inhibitor
    ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2. Learn More
  7. MIM1

    Catalog No. A16315
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    Mcl-1 inhibitor
    MIM1 is a selective small molecule inhibitor of Mcl-1(IC50= 4.8 μM) that overcomes Mcl-1-dependent leukemia cell survival. Learn More
  8. Obatoclax mesylate (GX15-070)

    Catalog No. A10665
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    Bcl-2 Inhibitor
    Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L). Learn More
  9. HA14-1

    Catalog No. A11448
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    Bcl-2 inhibitor
    HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2. Learn More
  10. AT-101

    Catalog No. A15004
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    Bcl-2 Inhibitor
    AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM. Learn More
  11. UMI-77

    Catalog No. A14222
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    Mcl-1 inhibitor
    UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family. Learn More
  12. Sabutoclax

    Catalog No. A12823
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    Bcl-2 inhibitor
    Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. Learn More
  13. AT101 acetic acid

    Catalog No. A13578
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    pan Bcl-2 inhibitor
    AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID Learn More
  14. A-1155463

    Catalog No. A16112
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    BCL-XL inhibitor
    A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM) Learn More
  15. A-1331852

    Catalog No. A16190
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    BCL-XL inhibitor
    A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML. Learn More
  16. TW-37

    Catalog No. A10955
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    Bcl-2 inhibitor
    TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1. Learn More
  17. BM-1074

    Catalog No. A12743
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    Bcl-2/Bcl-xL inhibitor
    BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM. Learn More
  18. (+)-Apogossypol

    Catalog No. A16316
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    Bcl-2 family inhibitor
    (+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM. Learn More
  19. Apogossypolone (ApoG2)

    Catalog No. A16314
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    Bcl-2 inhibitor
    Apogossypolone is a nonpeptidic small-molecule inhibitor of Bcl-2 with Learn More
  20. Acetate gossypol

    Catalog No. A14795
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    Bcl-2 Inhibitor
    Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic. Learn More
  21. (S)-Gossypol acetic acid

    Catalog No. A16323
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    (S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM). Learn More
  22. BH3I-1

    Catalog No. A16061
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    Bcl-XL antagonist
    BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL Learn More
  23. WEHI-539 hydrochloride

    Catalog No. A13327
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    Bcl-xL inhibitor
    WEHI-539 hydrochloride is a small-molecule inhibitor of BCL-xL with IC50 value of 1.1 nM. Learn More
  24. BDA-366

    Catalog No. A15821
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    Bcl-2 antagonist
    BDA-366 selectively inhibits BCL2, converting it to a cell death inducer. Learn More
  25. A-1210477

    Catalog No. A15545
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    MCL-1 inhibitor
    A-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines. Learn More
  26. BAM 7

    Catalog No. A12907
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    Bax activator
    BAM 7 binds the BAX trigger site with an EC50 ~ 3.3 μM as measured in a competitive FP assay using FITC-BIM SAHB and BAX. Learn More
  27. Bcl-2 Inhibitor

    Catalog No. A13580
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    Bcl-2 Inhibitor
    Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively). Learn More
  28. Gambogic acid

    Catalog No. A11988
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    Bcl-2 inhibitor
    Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively. Learn More
  29. Pyridoclax (MR-29072)

    Catalog No. A16380
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    Mcl-1 inhibitor
    Pyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM. Learn More
  30. Bax channel blocker

    Catalog No. A15335
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    Bax channel blocker
    Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM). Learn More
  31. Bax inhibitor peptide P5

    Catalog No. A15336
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    Bax inhibitor
    Bax inhibitor peptide P5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro. Learn More
  32. Bax inhibitor peptide V5

    Catalog No. A15337
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    Bax inhibitor
    Bax inhibitor peptide V5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro. Learn More
  33. Muristerone A

    Catalog No. A15340
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    EcR agonist
    Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax. Learn More
  34. CID5721353

    Catalog No. A16192
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    BCL6 inhibitor
    CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor). Learn More
  35. Bax inhibitor peptide, negative control

    Catalog No. A15338
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    Bax inhibitor
    Bax inhibitor peptide, negative control, negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro. Learn More

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