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Bcl-2 Family
Inhibitory Selectivity
Catalog No. | Inhibitor Name | Bcl-2 | Bcl-B | Bcl-w | Bcl-xL | Mcl-1 | A1 | Bax | Other |
---|---|---|---|---|---|---|---|---|---|
A10255 | ABT-737 | **** | * | *** | *** | ||||
A10022 | Navitoclax (ABT-263) | **** | **** | **** | ** | ** | |||
A10665 | Obatoclax Mesylate | *** | |||||||
A10955 | TW-37 | *** | * | *** | |||||
A12500 | Venetoclax | **** | *** | **** | |||||
A15004 | AT101 | ** | ** | *** | |||||
A11448 | HA14-1 | * | |||||||
A12823 | Sabutoclax | ** | ** | *** | ** | ||||
A15545 | A-1210477 | **** | |||||||
A14222 | UMI-77 | ** | |||||||
A11988 | Gambogic Acid | * | * | **** | * | * | * | Caspase | |
A12743 | BM-1074 | **** | **** | ||||||
A13327 | WEHI-539 hydrochloride | **** | |||||||
A15821 | BDA-366 | *** | |||||||
A16061 | BH3I-1 | * | p53 | ||||||
A16112 | A-1155463 | **** | |||||||
A16190 | A-1331852 | **** | |||||||
A16314 | Apogossypolone (ApoG2) |
Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
Bcl-2 Family Products
Bcl-2 Family New Products
Compare Solubility
Catalog No. | Product Name | Application | Product Information |
---|---|---|---|
A10022 SALE |
ABT-263 (Navitoclax) |
Bcl-2 inhibitor |
ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins .
|
A10255 SALE |
ABT-737 |
Bcl-2 Inhibitor |
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
|
A13005 |
WEHI539 |
Bcl-XL inhibitor |
WEHI539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM.
|
A12500 SALE |
ABT-199 (Venetoclax) |
Bcl-2 inhibitor |
ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
|
A10665 SALE |
Obatoclax mesylate (GX15-070) |
Bcl-2 Inhibitor |
Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).
|
A16315 |
MIM1 |
Mcl-1 inhibitor |
MIM1 is a selective small molecule inhibitor of Mcl-1(IC50= 4.8 μM) that overcomes Mcl-1-dependent leukemia cell survival.
|
A11448 SALE |
HA14-1 |
Bcl-2 inhibitor |
HA14-1 interacts with Bcl-2 and inhibits the antiapoptotic effect of Bcl-2.
|
A14222 SALE |
UMI-77 |
Mcl-1 inhibitor |
UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
|
A15004 |
AT-101
|
Bcl-2 Inhibitor |
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM.
|
A12823 |
Sabutoclax |
Bcl-2 inhibitor |
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
|
A13578 |
AT101 acetic acid |
pan Bcl-2 inhibitor |
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID
|
A16112 |
A-1155463 |
BCL-XL inhibitor |
A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki ??0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)
|
A16190 |
A-1331852 |
BCL-XL inhibitor |
A-1331852 is a potent and selective BCL-XL inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML.
|
A10955 |
TW-37 |
Bcl-2 inhibitor |
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.
|
A16316 |
(+)-Apogossypol |
Bcl-2 family inhibitor |
(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.
|
A12743 |
BM-1074 |
Bcl-2/Bcl-xL inhibitor |
BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM.
|
A16323 |
(S)-Gossypol acetic acid |
Bcl-2 inhibitor |
(S)-Gossypol acetic acid is a inhibitor of Bcl-2, potently induce cell death in Jurkat cells overexpressing Bcl-2 (IC50, 18.1μM) or Bcl-xL (IC50, 22.9μM).
|
A14795 |
Acetate gossypol |
Bcl-2 Inhibitor |
Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic.
|
A16314 |
Apogossypolone (ApoG2) |
Bcl-2 inhibitor |
Apogossypolone is a nonpeptidic small-molecule inhibitor of Bcl-2 with
|
A16061 SALE |
BH3I-1 |
Bcl-XL antagonist |
BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL
|
A15821 |
BDA-366 |
Bcl-2 antagonist |
BDA-366 selectively inhibits BCL2, converting it to a cell death inducer.
|
A15545 |
A-1210477 |
MCL-1 inhibitor |
A-1210477 is a potent and selective MCL-1 inhibitor. A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines.
|
A13327 |
WEHI-539 hydrochloride |
Bcl-xL inhibitor |
WEHI-539 hydrochloride is a small-molecule inhibitor of BCL-xL with IC50 value of 1.1 nM.
|
A12907 SALE |
BAM 7 |
Bax activator |
BAM 7 binds the BAX trigger site with an EC50 ~ 3.3 μM as measured in a competitive FP assay using FITC-BIM SAHB and BAX.
|
A13580 |
Bcl-2 Inhibitor |
Bcl-2 Inhibitor |
Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-XL in vitro (IC50 =10 uM and 7 uM, respectively).
|
A16380 |
Pyridoclax |
Mcl-1 inhibitor |
Pyridoclax is a potent Mcl-1 inhibitor with Kd value of 25 nM.
|
A16192 |
CID5721353 |
BCL6 inhibitor |
CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor).
|
A15340 |
Muristerone A
|
EcR agonist |
Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax.
|
A15338 |
Bax inhibitor peptide, negative control
|
Bax inhibitor |
Bax inhibitor peptide, negative control, negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.
|
A15336 |
Bax inhibitor peptide P5
|
Bax inhibitor |
Bax inhibitor peptide P5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
|
A15335 |
Bax channel blocker
|
Bax channel blocker |
Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM).
|
A11988 SALE |
Gambogic acid |
Bcl-2 inhibitor |
Gambogic acid is a natural product isolated from the Garcinia hanburyi tree. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
|
A15337 SALE |
Bax inhibitor peptide V5 |
Bax inhibitor |
Bax inhibitor peptide V5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
|
Catalog No. | Product Name | Product Information | Added |
---|---|---|---|
A15004 |
AT-101 |
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM.
|
2017-11-01 |
A15336 |
Bax inhibitor peptide P5 |
Bax inhibitor peptide P5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
|
2017-11-01 |
A15340 |
Muristerone A |
Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax.
|
2017-03-08 |
A15338 |
Bax inhibitor peptide, negative control |
Bax inhibitor peptide, negative control, negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.
|
2017-11-01 |
A15335 |
Bax channel blocker |
Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM).
|
2017-11-01 |
Cat. No. | Product Name | Water | DMSO | Ethanol |
---|---|---|---|---|
A11448 |
HA14-1 |
82 mg/mL (200.37 mM) | <1 mg/mL (<1 mM) | 82 mg/mL (200.37 mM) |
A10022 |
ABT-263 (Navitoclax) |
100 mg/mL (102.6 mM) | <1 mg/mL (<1 mM) | <1 mg/mL (<1 mM) |
A10255 |
ABT-737 |
100 mg/mL (122.93 mM) | <1 mg/mL (<1 mM) | <1 mg/mL (<1 mM) |
A12907 |
BAM 7 |
2 mg/mL (4.93 mM) | <1 mg/mL (<1 mM) | <1 mg/mL (<1 mM) |
A10955 |
TW-37 |
115 mg/mL (200.45 mM) | <1 mg/mL (<1 mM) | 4 mg/mL (6.97 mM) |
A10665 |
Obatoclax mesylate (GX15-070) |
83 mg/mL (200.73 mM) | <1 mg/mL (<1 mM) | <1 mg/mL (<1 mM) |
A14222 |
UMI-77 |
93 mg/mL (198.57 mM) | <1 mg/mL (<1 mM) | 93 mg/mL heating (198.57 mM) |
A13578 |
AT101 acetic acid |
116 mg/mL (200.48 mM) | <1 mg/mL (<1 mM) | 89 mg/mL (153.81 mM) |
A12500 |
ABT-199 (Venetoclax) |
100 mg/mL (115.14 mM) | <1 mg/mL (<1 mM) | <1 mg/mL (<1 mM) |
A12823 |
Sabutoclax |
100 mg/mL heating (142.69 mM) | <1 mg/mL (<1 mM) | 54 mg/mL heating (77.05 mM) |


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