SARS-CoV-IN-2 is a potent inhibitor of SARS-CoV replication, demonstrating anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. Additionally, it exhibits significant inhibition of P. falciparum strains, showing IC50 values of 21.5 nM and 30 nM for the 3D7 and W2 strains, respectively. SARS-CoV-IN-2 also mitigates HIV-1-induced cytopathic effects, with an EC50 of 2.9 μM in MT-4 cells. This compound is valuable for research applications targeting both antiviral and antimalarial activities.
SARS-CoV-IN-2 is a potent inhibitor of SARS-CoV replication, demonstrating anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. Additionally, it exhibits significant inhibition of P. falciparum strains, showing IC50 values of 21.5 nM and 30 nM for the 3D7 and W2 strains, respectively. SARS-CoV-IN-2 also mitigates HIV-1-induced cytopathic effects, with an EC50 of 2.9 μM in MT-4 cells. This compound is valuable for research applications targeting both antiviral and antimalarial activities.
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