SB 218795 is a selective non-peptide antagonist of the neurokinin-3 (NK3) receptor, exhibiting a Ki of 13 nM for human NK3 (hNK3). This compound demonstrates significant selectivity, being approximately 90-fold and 7000-fold more potent against hNK3 compared to human NK2 and NK1 receptors, respectively. Research applications include studying the role of NK3 receptors in neurobiology and investigating potential therapeutic targets for managing related disorders. Additionally, SB 218795 has been shown to inhibit NK3 receptor-mediated pupillary constriction in rabbits, presenting further opportunities for exploration in translational research.
SB 218795 is a selective non-peptide antagonist of the neurokinin-3 (NK3) receptor, exhibiting a Ki of 13 nM for human NK3 (hNK3). This compound demonstrates significant selectivity, being approximately 90-fold and 7000-fold more potent against hNK3 compared to human NK2 and NK1 receptors, respectively. Research applications include studying the role of NK3 receptors in neurobiology and investigating potential therapeutic targets for managing related disorders. Additionally, SB 218795 has been shown to inhibit NK3 receptor-mediated pupillary constriction in rabbits, presenting further opportunities for exploration in translational research.
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