Fig. 1 · Structure
Documents & Downloads
SB 218795
NK3 Receptor Antagonist
SB 218795 is a selective non-peptide antagonist of the neurokinin-3 (NK3) receptor, exhibiting a Ki of 13 nM for human NK3 (hNK3). This compound demonstrates significant selectivity, being approximately 90-fold and 7000-fold more potent against hNK3 compared to human NK2 and NK1 receptors, respectively. Research applications include studying the role of NK3 receptors in neurobiology and investigating potential therapeutic targets for managing related disorders. Additionally, SB 218795 has been shown to inhibit NK3 receptor-mediated pupillary constriction in rabbits, presenting further opportunities for exploration in translational research.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 174635-53-1 |
| Applications | NK3 Receptor Antagonist |
| Formula | C25H20N2O3 |
| Molecular Weight | 396.44 |
| SMILES | COC([C@@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=CC=C3)=NC4=CC=CC=C24)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.