SB 220025 (tri(hydrochloride)) is a reversible, orally active, ATP-competitive inhibitor of human p38 MAPK, with an IC50 of 60 nM. This compound also exhibits inhibition of p56Lck and PKC with IC50 values of 3.5 μM and 2.89 μM, respectively. SB 220025 trihydrochloride effectively reduces IL-8 gene expression in response to globular adiponectin and diminishes inflammatory cytokine production, making it a valuable tool for studying inflammation and angiogenesis. Additionally, it has shown efficacy in preventing the progression of arthritis in chronic inflammatory disease models.
SB 220025 (tri(hydrochloride)) is a reversible, orally active, ATP-competitive inhibitor of human p38 MAPK, with an IC50 of 60 nM. This compound also exhibits inhibition of p56Lck and PKC with IC50 values of 3.5 μM and 2.89 μM, respectively. SB 220025 trihydrochloride effectively reduces IL-8 gene expression in response to globular adiponectin and diminishes inflammatory cytokine production, making it a valuable tool for studying inflammation and angiogenesis. Additionally, it has shown efficacy in preventing the progression of arthritis in chronic inflammatory disease models.
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