Fig. 1 · Structure
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SB 235375
Neurokinin Receptor Antagonist
SB 235375 is a selective antagonist of the human neurokinin-3 (hNK-3) receptor, developed through structural optimization of 2-phenyl-4-quinolinecarboxylic acid amide. It exhibits high affinity specifically for the hNK-3 receptor, showing significantly lower binding to hNK-1 and hNK-2 receptors. In vitro, SB 235375 effectively inhibits NK-3 receptor-mediated contraction and calcium mobilization. Additionally, in vivo studies reveal its capability to attenuate NK-3 receptor-driven responses through both oral and intravenous administration in animal models. This makes SB 235375 a valuable tool for research in neurokinin signaling and related physiological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 224961-34-6 |
| Applications | Neurokinin Receptor Antagonist |
| Formula | C27H24N2O4 |
| Molecular Weight | 440.49 |
| SMILES | O=C(N[C@H](C1=CC=CC=C1)CC)C2=C(C(C3=CC=CC=C3)=NC4=CC=CC=C24)OCC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.