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Biological Activity
SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested.
Targets
| CXCR2 | ||||
| 22 nM |
| In vitro (25°C) | DMSO | 64 mg/mL (181.74 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 3 mg/mL (8.51 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.4 mL | 141.99 mL | 283.98 mL |
| 0.5 mM | 5.68 mL | 28.4 mL | 56.8 mL |
| 1 mM | 2.84 mL | 14.2 mL | 28.4 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
*The above data is based on the productmolecular weight 352.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14209 |
|---|---|
| Actions | Antagonist |
| CAS No. | 182498-32-4 |
| Formula | C13H10BrN3O4 |
| M. Wt | 352.14 |
| Purity | >98% |
| Synonyms | SB-225002, SB 225002 |
| SMILES | C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
United StatesAdooq Bioscience
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Email: [email protected]
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