Fig. 1 · Structure
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SC 51089 free base
EP1 Antagonist
SC 51089 free base acts as a selective antagonist of the prostaglandin E2 EP1 receptor, displaying inhibitory constants (Kis) of 1.3 μM for EP1, 11.2 μM for TP, 17.5 μM for EP3, and 61.1 μM for FP receptors. This compound demonstrates notable neuroprotective activity, making it valuable for research in neurobiology and inflammation studies. Its specificity towards the EP1 receptor positions SC 51089 free base as an important tool for investigating the effects of prostaglandin signaling in various biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 146033-03-6 |
| Applications | EP1 Antagonist |
| Formula | C22H19ClN4O3 |
| Molecular Weight | 422.86 |
| SMILES | O=C(N1C2=CC(Cl)=CC=C2OC3=CC=CC=C3C1)NNC(CCC4=CC=NC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.