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Biological Activity
SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.31 mL | 101.54 mL | 203.07 mL |
| 0.5 mM | 4.06 mL | 20.31 mL | 40.61 mL |
| 1 mM | 2.03 mL | 10.15 mL | 20.31 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
*The above data is based on the productmolecular weight 492.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21554 |
|---|---|
| Actions | Antagonist |
| CAS No. | 906805-42-3 |
| Formula | C23H31Cl2N7O |
| M. Wt | 492.44 |
| Purity | >98% |
| Synonyms | SCH546738, SCH-546738 |
| SMILES | O=C(N)C1=NC(Cl)=C(N2CCN(C3CCN(CC4=CC=C(Cl)C=C4)CC3)[C@@H](CC)C2)N=C1N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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