SGI-1776 (free base)

Catalog No.: A10838

PIM1 Inhibitor

SGI-1776 (free base)

SGI-1776 (free base) Chemical Structure

CAS NO. 1025065-69-3

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

Availability: In stock

Package Price Qty
5 mg
$85.00
10 mg
$150.00
25 mg
$280.00
50 mg
$410.00
10mM * 1mL in DMSO
$95.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Ishikawa C, .et al. Expression and significance of Pim-3 kinase in adult T-cell leukemia, Eur J Haematol, 2017, Dec;99(6):495-504 PMID: 28833639

Biological Activity

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
In vitro (25°C) DMSO 70 mg/mL (172.66 mM)
Water Insoluble
Ethanol 70 mg/mL (172.66 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.67 mL 123.33 mL 246.67 mL
0.5 mM 4.93 mL 24.67 mL 49.33 mL
1 mM 2.47 mL 12.33 mL 24.67 mL
5 mM 0.49 mL 2.47 mL 4.93 mL

*The above data is based on the productmolecular weight 405.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10838
Actions Inhibitor
CAS No. 1025065-69-3
Formula C20H22F3N5O
M. Wt 405.4
Purity >98%
Synonyms SGI1776
SMILES CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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