SGI-1776 (free base)

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
Grouped product items
Product Name Price Stock Qty
SGI-1776 5mg
$85.00
In stock
SGI-1776 10mg
$150.00
In stock
SGI-1776 25mg
$280.00
In stock
SGI-1776 50mg
$410.00
In stock
SGI-1776 (free base) 10mM * 1mL in DMSO
$95.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Adooq's SGI-1776 (free base) has been cited by 1 publications
  • Ishikawa C, .et al. , Eur J Haematol, 2017, Dec;99(6):495-504 PMID: 28833639
  • Biological Activity
    Discription SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
    Product Information
    Catalog Num A10838
    Formula C20H22F3N5O
    Molecular Weight 405.4
    CAS Number 1025065-69-3
    SMILES CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
    Synonyms SGI1776
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 70 mg/mL (172.66 mM)
    Water Insoluble
    Ethanol 70 mg/mL (172.66 mM)
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.67 mL 123.33 mL 246.67 mL
    0.5 mM 4.93 mL 24.67 mL 49.33 mL
    1 mM 2.47 mL 12.33 mL 24.67 mL
    5 mM 0.49 mL 2.47 mL 4.93 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy SGI-1776 (free base) | SGI-1776 (free base) Supplier | purchase SGI-1776 (free base) | SGI-1776 (free base) cost | SGI-1776 (free base) manufacturer | order SGI-1776 (free base) | SGI-1776 (free base) distributor | buy 1025065-69-3 | 1025065-69-3 Supplier | purchase 1025065-69-3 | 1025065-69-3 cost | 1025065-69-3 manufacturer | order 1025065-69-3 | 1025065-69-3 distributor