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SGI-1776 (free base)


PIM1 Inhibitor

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Catalog No. A10838

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SGI-1776 5mg A10838-5

Regular Price: $85.00

Special Price: $76.50

SGI-1776 10mg A10838-10

Regular Price: $150.00

Special Price: $135.00

SGI-1776 25mg A10838-25

Regular Price: $280.00

Special Price: $252.00

SGI-1776 50mg A10838-50

Regular Price: $410.00

Special Price: $369.00

SGI-1776 (free base) 10mM * 1mL in DMSO A10838-10mM-D

Regular Price: $95.00

Special Price: $85.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.

SGI-1776 (free base)

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Publications citing Adooq Products
SGI-1776 (free base) Citations (1)
  • Ishikawa C, .et al. Expression and significance of Pim-3 kinase in adult T-cell leukemia, Eur J Haematol, 2017, Dec;99(6):495-504 PMID: 28833639

Chemical Information

Catalog Num A10838
Actions Inhibitor
M. Wt 405.4
Formula C20H22F3N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1025065-69-3
Synonyms SGI1776

Biological Activity

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.


Solubility (25°C) * In vitro DMSO 81 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 81 mg/mL (199.79 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.67 mL 123.33 mL 246.67mL
0.5 mM 4.93 mL 24.67 mL 49.33 mL
1 mM 2.47 mL 12.33 mL 24.67 mL
5 mM 0.49 mL 2.47 mL 4.93 mL

*The above data is based on the productmolecular weight 405.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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