United States
You have no items in your shopping cart.
Publications citing Adooq Products
SGI-1776 (free base) Citations (1)
- Ishikawa C,et al. Expression and significance of Pim-3 kinase in adult T-cell leukemia, Eur J Haematol, 2017, Dec;99(6):495-504 28833639
Chemical Information
| Catalog Num | A10838 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 405.4 |
| Formula | C20H22F3N5O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1025065-69-3 |
| Synonyms | SGI1776 |
| SMILES code | CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2 |
| Chemical Name | N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine sulfate |
Description |
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1. | |||||
| Solubility (25°C) * | In vitro | DMSO | 81 mg/mL (199.79 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 81 mg/mL (199.79 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.67 mL | 123.33 mL | 246.67mL |
| 0.5 mM | 4.93 mL | 24.67 mL | 49.33 mL |
| 1 mM | 2.47 mL | 12.33 mL | 24.67 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
*The above data is based on the productmolecular weight 405.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
$60.00
INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively; ...
Special Price Starting at: $60.00
Special Price Starting at:
$80.00
WHI-P 154 is a JAK3 inhibitor with IC50 = 1.8uM. WHI-P 154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. ...
Special Price Starting at: $80.00
Special Price Starting at:
$54.00
TG-101348 is an orally bioavailable, ATP-competitive and selective inhibitor of Janus-associated kinase 2 with potential antineoplastic activity. ...
Special Price Starting at: $54.00
Special Price Starting at:
$110.00
FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 uM. ...
Special Price Starting at: $110.00
Special Price Starting at:
$81.00
PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately i ...
Special Price Starting at: $81.00
Special Price Starting at:
$27.00
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src. ...
Special Price Starting at: $27.00
Special Price Starting at:
$90.00
ZM 39923 HCl is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 M, respectively) ...
Special Price Starting at: $90.00
Special Price Starting at:
$140.00
Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3. ...
Special Price Starting at: $140.00
Special Price Starting at:
$45.00
R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. ...
Special Price Starting at: $45.00
Special Price Starting at:
$60.00
Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex. ...
Special Price Starting at: $60.00
Special Price Starting at:
$54.00
WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation. ...
Special Price Starting at: $54.00
Special Price Starting at:
$45.00
AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. ...
Special Price Starting at: $45.00
Special Price Starting at:
$70.00
AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively. ...
Special Price Starting at: $70.00
Special Price Starting at:
$180.00
AZ-960 is a potent, selective and ATP competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell. ...
Special Price Starting at: $180.00
Special Price Starting at:
$135.00
CEP33779 is a selective JAK2 inhibitor with IC50 of 1.8 nM. ...
Special Price Starting at: $135.00
Special Price Starting at:
$81.00
CYT387 is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. ...
Special Price Starting at: $81.00
Special Price Starting at:
$67.50
Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. ...
Special Price Starting at: $67.50
Special Price Starting at:
$85.00
TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases. ...
Special Price Starting at: $85.00
Special Price Starting at:
$36.00
VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases. ...
Special Price Starting at: $36.00
Special Price Starting at:
$100.00
AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. ...
Special Price Starting at: $100.00
Special Price Starting at:
$90.00
BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. ...
Special Price Starting at: $90.00
Special Price Starting at:
$45.00
AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM. ...
Special Price Starting at: $45.00
Special Price Starting at:
$67.50
Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively. ...
Special Price Starting at: $67.50
Special Price Starting at:
$70.00
TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.
...
Special Price Starting at: $70.00
TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.
...
Keywords:buy SGI-1776 (free base) | SGI-1776 (free base) Supplier | purchase SGI-1776 (free base) | SGI-1776 (free base) cost | SGI-1776 (free base) manufacturer | order SGI-1776 (free base) | SGI-1776 (free base) distributor | buy 1025065-69-3 | 1025065-69-3 Supplier | purchase 1025065-69-3 | 1025065-69-3 cost | 1025065-69-3 manufacturer | order 1025065-69-3 | 1025065-69-3 distributor
We Using Safe Payments:
