SGI-1776 (free base)

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
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2mg
$40.00
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5mg
$80.00
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10mg
$145.00
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25mg
$275.00
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50mg
$405.00
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100mg
$585.00
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10mM * 1mL in DMSO
$90.00
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Adooq Products cited in reputable paper
Adooq's SGI-1776 (free base) has been cited by 1 publications
  • Ishikawa C, .et al. , Eur J Haematol, 2017, Dec;99(6):495-504 PMID: 28833639
  • Biological Activity
    Discription SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1.
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A10838
    Formula C20H22F3N5O
    Molecular Weight 405.4
    CAS Number 1025065-69-3
    SMILES CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
    Synonyms SGI1776
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 70 mg/mL (172.66 mM)
    Water Insoluble
    Ethanol 70 mg/mL (172.66 mM)
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.67 mL 123.33 mL 246.67 mL
    0.5 mM 4.93 mL 24.67 mL 49.33 mL
    1 mM 2.47 mL 12.33 mL 24.67 mL
    5 mM 0.49 mL 2.47 mL 4.93 mL
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