Sivelestat

Catalog No.: A14184

Neutrophil elastase inhibitor

Sivelestat

Sivelestat Chemical Structure

CAS NO. 127373-66-4

Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).

Availability: In stock

Package Price Qty
10 mg
$65.00
25 mg
$130.00
50 mg
$240.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).
Targets
neutrophil elastase
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.02 mL 115.09 mL 230.17 mL
0.5 mM 4.6 mL 23.02 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A14184
Actions Inhibitor
M. Wt 434.46
Formula C20H22N2O7S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 127373-66-4
Synonyms Elastase Inhibitor IV
SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O

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