Sivelestat

Catalog No.: A14184

Neutrophil elastase inhibitor

Sivelestat

Sivelestat Chemical Structure

CAS NO. 127373-66-4

Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).

Availability: In stock

Package Price Qty
10 mg
$65.00
25 mg
$130.00
50 mg
$240.00
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Biological Activity

Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase).
Targets
neutrophil elastase
In vitro (25°C) DMSO 76 mg/mL (174.92 mM)
Water Insoluble
Ethanol 76 mg/mL (174.92 mM)
In vivo 5% DMSO+40% PEG 300+5% Tween 80+ddH2O 21 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.02 mL 115.09 mL 230.17 mL
0.5 mM 4.6 mL 23.02 mL 46.03 mL
1 mM 2.3 mL 11.51 mL 23.02 mL
5 mM 0.46 mL 2.3 mL 4.6 mL

*The above data is based on the productmolecular weight 434.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14184
Actions Inhibitor
CAS No. 127373-66-4
Formula C20H22N2O7S
M. Wt 434.46
Purity >98%
Synonyms Elastase Inhibitor IV
SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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