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Splitomicin

NAD(+)-dependent histone deacetylase Sir2p inhibitor

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Catalog No. A14221

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Splitomicin 10mg A14221-10
$70.00
Splitomicin 25mg A14221-25
$140.00
Splitomicin 50mg A14221-50
$220.00
Splitomicin 10mM * 1mL in DMSO A14221-10mM-D
$73.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay.

Splitomicin

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Chemical Information

Catalog Num A14221
Actions Inhibitor
M. Wt 198.22
Formula C13H10O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. CAS: 5690-03-9
Synonyms N/A
SMILES C1CC(=O)OC2=C1C3=CC=CC=C3C=C2

Biological Activity

Description
Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay.
Targets
Sir2p
60 μM

Solubility

Solubility (25°C)* In vitro DMSO 39 mg/mL (196.75 mM)
Water <1 mg/mL (<1 mM)
Ethanol 39 mg/mL (196.75 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 50.45 mL 252.24 mL 504.49mL
0.5 mM 10.09 mL 50.45 mL 100.9 mL
1 mM 5.04 mL 25.22 mL 50.45 mL
5 mM 1.01 mL 5.04 mL 10.09 mL

*The above data is based on the productmolecular weight 198.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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