SR-717 free acid is a non-nucleotide STING agonist that demonstrates effective activation in immune responses, exhibiting EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 wild-type and cGAS knockout cell lines, respectively. This compound serves as a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic, enhancing antitumor activity through stimulation of the STING pathway. Its potential applications in cancer immunotherapy and the study of innate immunity make it a valuable tool for researchers in the field of immunology.
SR-717 free acid is a non-nucleotide STING agonist that demonstrates effective activation in immune responses, exhibiting EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 wild-type and cGAS knockout cell lines, respectively. This compound serves as a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic, enhancing antitumor activity through stimulation of the STING pathway. Its potential applications in cancer immunotherapy and the study of innate immunity make it a valuable tool for researchers in the field of immunology.
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