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SRT1720 HCl


SIRT1 Activator

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Catalog No. A10862

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SRT1720 5mg A10862-5

Regular Price: €85.50

Special Price: €76.95

SRT1720 10mg A10862-10

Regular Price: €152.00

Special Price: €136.80

SRT1720 50mg A10862-50

Regular Price: €427.50

Special Price: €384.75

SRT1720 200mg A10862-200

Regular Price: €1,140.00

Special Price: €1,026.00

SRT1720 10mM * 1mL in DMSO A10862-10mM-D

Regular Price: €142.50

Special Price: €128.25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.

SRT1720 HCl

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Publications citing Adooq Products
SRT1720 HCl Citations (6)
  • Jie Ren, .et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 PMID: 30411173
  • Rowlands BD, .et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
  • Adam Khader, .et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
  • Adam Khader, .et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651-e663 PMID: 26963320
  • Benjamin D. Rowlands, .et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
  • Khader A, .et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 PMID: 24918615

Chemical Information

Catalog Num A10862
Actions Activator
M. Wt 506.0
Formula C25H23N7OS.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1001645-58-4
Synonyms SRT-1720

Biological Activity

SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
SIRT1 (Cell-free assay)
0.16 μM(EC50)


Solubility (25°C) * In vitro DMSO 38 mg/mL (75.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.76 mL 98.81 mL 197.63mL
0.5 mM 3.95 mL 19.76 mL 39.53 mL
1 mM 1.98 mL 9.88 mL 19.76 mL
5 mM 0.4 mL 1.98 mL 3.95 mL

*The above data is based on the productmolecular weight 506.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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