Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order

SRT1720 HCl

Catalog No.: A10862

SIRT1 Activator

SRT1720 HCl

SRT1720 HCl Chemical Structure

CAS NO. 1001645-58-4

SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.

Availability: In stock

Package Price Qty
5 mg
10 mg
50 mg
200 mg
10mM * 1mL in DMSO
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
  • Jie Ren, .et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 PMID: 30411173
  • Rowlands BD, .et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
  • Adam Khader, .et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
  • Adam Khader, .et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651-e663 PMID: 26963320
  • Benjamin D. Rowlands, .et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
  • Khader A, .et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 PMID: 24918615

Biological Activity

SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
SIRT1 (Cell-free assay)
0.16 μM(EC50)
In vitro DMSO 34 mg/mL (67.19 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.76 mL 98.81 mL 197.63 mL
0.5 mM 3.95 mL 19.76 mL 39.53 mL
1 mM 1.98 mL 9.88 mL 19.76 mL
5 mM 0.4 mL 1.98 mL 3.95 mL

*The above data is based on the productmolecular weight 506.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10862
Actions Activator
CAS No. 1001645-58-4
Formula C25H23N7OS.HCl
M. Wt 506.0
Purity >98%
Synonyms SRT-1720

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy SRT1720 HCl | SRT1720 HCl Supplier | purchase | cost | manufacturer | order | distributor | buy 1001645-58-4| 1001645-58-4 Supplier | purchase 1001645-58-4 | 1001645-58-4 cost | 1001645-58-4 manufacturer | order 1001645-58-4 | 1001645-58-4 distributor