SRT1720 HCl

Catalog No.: A10862

SIRT1 Activator

SRT1720 HCl

SRT1720 HCl Chemical Structure

CAS NO. 1001645-58-4

SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.

Availability: In stock

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5 mg
10 mg
50 mg
200 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Jie Ren, .et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 PMID: 30411173
  • Rowlands BD, .et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
  • Adam Khader, .et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
  • Adam Khader, .et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651-e663 PMID: 26963320
  • Benjamin D. Rowlands, .et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
  • Khader A, .et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 PMID: 24918615

Biological Activity

SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
SIRT1 (Cell-free assay)
0.16 μM(EC50)
In vitro (25°C) DMSO 38 mg/mL (75.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.76 mL 98.81 mL 197.63 mL
0.5 mM 3.95 mL 19.76 mL 39.53 mL
1 mM 1.98 mL 9.88 mL 19.76 mL
5 mM 0.4 mL 1.98 mL 3.95 mL

*The above data is based on the productmolecular weight 506.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10862
Actions Activator
M. Wt 506.0
Formula C25H23N7OS.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1001645-58-4
Synonyms SRT-1720

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