SRT1720 HCl

Name: SRT1720 HCl
Brand: Adooq Bioscience
SKU: A10862
Rating: 100 (7 reviews)

Catalog No.: A10862

SIRT1 Activator

Product Citations (7)

SRT1720 HCl Chemical Structure

CAS NO. 1001645-58-4

SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$160.00
50 mg	$450.00
200 mg	$1,200.00
10mM * 1mL in DMSO	$150.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq SRT1720 HCl

Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
Jie Ren, .et al. Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice, Sleep Breath, 2018, Nov 8 PMID: 30411173
Rowlands BD, .et al. Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation, J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
Adam Khader, .et al. SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis, J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
Adam Khader, .et al. Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy, Crit Care Med, 2016, Aug; 44(8): e651-e663 PMID: 26963320
Benjamin D. Rowlands, .et al. Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism., J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
Khader A, .et al. Sirtuin 1 activation stimulates mitochondrial biogenesis and attenuates renal injury after ischemia-reperfusion., Transplantation, 2014, 98(2):148-56 PMID: 24918615

Biological Activity

SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.

Targets

SIRT1 (Cell-free assay)
0.16 μM(EC50)

Solubility *

In vitro	DMSO	34 mg/mL (67.19 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.76 mL	98.81 mL	197.63 mL
0.5 mM	3.95 mL	19.76 mL	39.53 mL
1 mM	1.98 mL	9.88 mL	19.76 mL
5 mM	0.4 mL	1.98 mL	3.95 mL

*The above data is based on the productmolecular weight 506.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10862
Actions	Activator
CAS No.	1001645-58-4
Formula	C25H23N7OS.HCl
M. Wt	506.0
Solubility	DMSO
Purity	>98%
Synonyms	SRT-1720
SMILES	C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.