SSE1806 is a microtubule/tubulin inhibitor derived from podophyllotoxin, exhibiting notable anticancer and antiproliferative effects. It demonstrates a GI50 range of 1.29-21.15 μM against cancer cell growth, inducing mitotic abnormalities and G2/M phase cell cycle arrest. Additionally, SSE1806 enhances p53 expression and effectively inhibits the growth of colon cancer organoids, while also overcoming multidrug resistance in MDR-1 overexpressing cell lines, making it a valuable tool for cancer research.
SSE1806 is a microtubule/tubulin inhibitor derived from podophyllotoxin, exhibiting notable anticancer and antiproliferative effects. It demonstrates a GI50 range of 1.29-21.15 μM against cancer cell growth, inducing mitotic abnormalities and G2/M phase cell cycle arrest. Additionally, SSE1806 enhances p53 expression and effectively inhibits the growth of colon cancer organoids, while also overcoming multidrug resistance in MDR-1 overexpressing cell lines, making it a valuable tool for cancer research.
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