STING agonist-28 is a non-nucleotide small-molecule that serves as a potent agonist for the Stimulator of Interferon Genes (STING) pathway. It activates STING, leading to the phosphorylation of key proteins including TBK1 and IRF3. This compound significantly enhances the production of pro-inflammatory cytokines such as IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells, making it valuable for immunotherapy research. Additionally, STING agonist-28 demonstrates antiviral activity against various SARS-CoV strains, highlighting its potential in antiviral research applications.
STING agonist-28 is a non-nucleotide small-molecule that serves as a potent agonist for the Stimulator of Interferon Genes (STING) pathway. It activates STING, leading to the phosphorylation of key proteins including TBK1 and IRF3. This compound significantly enhances the production of pro-inflammatory cytokines such as IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells, making it valuable for immunotherapy research. Additionally, STING agonist-28 demonstrates antiviral activity against various SARS-CoV strains, highlighting its potential in antiviral research applications.
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