t-Boc-Aminooxy-PEG5-azide is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This linker is valuable for researchers developing targeted protein degradation strategies in chemical biology and therapeutic applications.
t-Boc-Aminooxy-PEG5-azide is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This linker is valuable for researchers developing targeted protein degradation strategies in chemical biology and therapeutic applications.
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