Talatisamine is an orally active cyclophilin D activator derived from the roots of Aconitum carmichaeli Debx. It functions primarily by preventing calcium-dependent opening of the mitochondrial permeability transition pore (mPTP) with an IC50 of 78 μM and inhibiting delayed rectifier K+ channels with an IC50 of 146 μM. Talatisamine demonstrates significant antioxidant and membrane-stabilizing properties, effectively inhibiting lipid peroxidation and preserving mitochondrial membrane integrity. Its diverse biological activities include antiarrhythmic, hypotensive, anti-inflammatory, anticancer, and neuroprotective effects, making it a valuable tool in the study of ischemic diseases, rheumatoid arthritis, inflammation-related conditions, and Alzheimer's disease.
Talatisamine is an orally active cyclophilin D activator derived from the roots of Aconitum carmichaeli Debx. It functions primarily by preventing calcium-dependent opening of the mitochondrial permeability transition pore (mPTP) with an IC50 of 78 μM and inhibiting delayed rectifier K+ channels with an IC50 of 146 μM. Talatisamine demonstrates significant antioxidant and membrane-stabilizing properties, effectively inhibiting lipid peroxidation and preserving mitochondrial membrane integrity. Its diverse biological activities include antiarrhythmic, hypotensive, anti-inflammatory, anticancer, and neuroprotective effects, making it a valuable tool in the study of ischemic diseases, rheumatoid arthritis, inflammation-related conditions, and Alzheimer's disease.
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