Tamarixetin, a 4'-O-Methyl Quercetin derivative, serves as a potent inhibitor of the caseinolytic protease P (ClpP) and exhibits significant anti-inflammatory and antioxidant properties. This natural flavonoid effectively inhibits ClpP's hydrolytic activity towards the substrate Suc-LY-AMC with an IC50 of 49.73 μM, making it relevant for research involving Staphylococcus aureus infections. Additionally, Tamarixetin demonstrates the ability to inhibit tumor cell growth, induce apoptosis, and induce cell cycle arrest, while also preventing cardiac hypertrophy through the modulation of NFAT and AKT signaling pathways.
Tamarixetin, a 4'-O-Methyl Quercetin derivative, serves as a potent inhibitor of the caseinolytic protease P (ClpP) and exhibits significant anti-inflammatory and antioxidant properties. This natural flavonoid effectively inhibits ClpP's hydrolytic activity towards the substrate Suc-LY-AMC with an IC50 of 49.73 μM, making it relevant for research involving Staphylococcus aureus infections. Additionally, Tamarixetin demonstrates the ability to inhibit tumor cell growth, induce apoptosis, and induce cell cycle arrest, while also preventing cardiac hypertrophy through the modulation of NFAT and AKT signaling pathways.
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