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Biological Activity
TAPI-2 is an inhibitor of TACE, ADAMs, ACE secretase, and other MMPs (metalloproteinases). TAPI-2 blocks release of DCC7, APP, TNFα, L-selectin, NOTCH, TGFα, IL-6R9, erbB2/HER2, and ACE. This inhibitor has been used in tissue culture.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.07 mL | 120.33 mL | 240.66 mL |
| 0.5 mM | 4.81 mL | 24.07 mL | 48.13 mL |
| 1 mM | 2.41 mL | 12.03 mL | 24.07 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.81 mL |
*The above data is based on the productmolecular weight 415.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14009 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 187034-31-7 |
| Formula | C19H37N5O5 |
| M. Wt | 415.53 |
| Purity | >98% |
| Synonyms | TNF Protease Inhibitor 2 |
| SMILES | C[[email protected]@H](C(=O)NCCN)NC(=O)[[email protected]](C(C)(C)C)NC(=O)C(CC(C)C)CC(=O)NO |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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