Taurohyodeoxycholic acid, an endogenous metabolite and 6 alpha-hydroxylated bile acid, exhibits anti-inflammatory properties by significantly reducing colonic myeloperoxidase (MPO) activity, TNF-α, IL-6 serum levels, and COX-2 expression. It has been shown to alleviate ulcerative colitis induced by trinitrobenzene sulfonic acid by modulating the balance between Th1/Th2 and Th17/Treg cells. Additionally, taurohyodeoxycholic acid improves outcomes in high-fat diet-induced nonalcoholic fatty liver disease in murine models and protects against hepatotoxicity in bile fistula rats. This compound is valuable for research into nonalcoholic fatty liver disease (NAFLD), colitis, and biliary fistula conditions.
Taurohyodeoxycholic acid, an endogenous metabolite and 6 alpha-hydroxylated bile acid, exhibits anti-inflammatory properties by significantly reducing colonic myeloperoxidase (MPO) activity, TNF-α, IL-6 serum levels, and COX-2 expression. It has been shown to alleviate ulcerative colitis induced by trinitrobenzene sulfonic acid by modulating the balance between Th1/Th2 and Th17/Treg cells. Additionally, taurohyodeoxycholic acid improves outcomes in high-fat diet-induced nonalcoholic fatty liver disease in murine models and protects against hepatotoxicity in bile fistula rats. This compound is valuable for research into nonalcoholic fatty liver disease (NAFLD), colitis, and biliary fistula conditions.
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