tert-Butyl 3,3-difluoro-4-((methylsulfonyloxy)methyl)piperidine-1-carboxylate

Catalog No.: A84251
PROTAC Linker
tert-Butyl 3,3-difluoro-4-((methylsulfonyloxy)methyl)piperidine-1-carboxylate serves as a specialized PROTAC linker, facilitating the development of targeted protein degradation therapeutics. This compound enhances the stability and efficacy of PROTACs by promoting effective ternary complex formation between E3 ligases and target proteins. Its application in chemical biology underscores its importance in novel therapeutic strategies aimed at selectively degrading specific proteins involved in various diseases.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptiontert-Butyl 3,3-difluoro-4-((methylsulfonyloxy)methyl)piperidine-1-carboxylate serves as a specialized PROTAC linker, facilitating the development of targeted protein degradation therapeutics. This compound enhances the stability and efficacy of PROTACs by promoting effective ternary complex formation between E3 ligases and target proteins. Its application in chemical biology underscores its importance in novel therapeutic strategies aimed at selectively degrading specific proteins involved in various diseases.
Product Information
Catalog NumA84251
FormulaC12H21F2NO5S
Molecular Weight329.36
CAS Number1864060-27-4
SMILESO=C(OC(C)(C)C)N1CCC(COS(=O)(=O)C)C(F)(F)C1
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